Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor
We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing...
Gespeichert in:
| Veröffentlicht in: | Radiation research 2001-11, Vol.156 (5), p.510-520 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 520 |
|---|---|
| container_issue | 5 |
| container_start_page | 510 |
| container_title | Radiation research |
| container_volume | 156 |
| creator | Zhao, Dawen Constantinescu, Anca Hahn, Eric W. Mason, Ralph P. |
| description | We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors $( |
| doi_str_mv | 10.1667/0033-7587(2001)156[0510:TODWRT]2.0.CO;2 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72207030</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3580573</jstor_id><sourcerecordid>3580573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c328t-520fa249d0fd7f1c4f2f825de2d8115d3e78400d9af488904eb67fc1418dbb183</originalsourceid><addsrcrecordid>eNpFkE9rGzEQxUVpaZyk36AUXVqawzqjfytteip2mxgCLsalh1KMvJLsDbuSI2mTGvLhuyRuchrmzW_mDQ-hcwJjUpbyHICxQgolP1MAckZE-RsEgYvlfPprsfxDxzCezL_QV2hEKqYKwYG_RqPnrSN0nNINDD0pq7foiJASOJR8hB6WfRcinv_db6zH073XXVMnfN_kLV7YtLN1xjngyxjuB0V786g2UecQ93iy1W1r_cZe4Jm_syk3G52b4HFwOG8tnvbeN36Df8SQss4WLxijsria4UfbU_TG6TbZd4d6gn5-_7acXBXX88vZ5Ot1UTOqciEoOE15ZcAZ6UjNHXWKCmOpUYQIw6xUHMBU2nGlKuB2XUpXE06UWa-JYifo09PdXQy3_fDmqmtSbdtWexv6tJKUggQGA_jhAPbrzprVLjadjvvV_7wG4OMB0KnWrYva10164TihjIpy4N4_cTdpCOp5zoQCIRn7Bwa8iOU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72207030</pqid></control><display><type>article</type><title>Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>BioOne Complete</source><creator>Zhao, Dawen ; Constantinescu, Anca ; Hahn, Eric W. ; Mason, Ralph P.</creator><creatorcontrib>Zhao, Dawen ; Constantinescu, Anca ; Hahn, Eric W. ; Mason, Ralph P.</creatorcontrib><description>We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors $(<1\ {\rm cm}^{3})$, the mean $p{\rm O}_{2}$ ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with $p{\rm O}_{2}\ <10$ Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the faster-growing rat prostate tumors investigated previously.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.1667/0033-7587(2001)156[0510:TODWRT]2.0.CO;2</identifier><identifier>PMID: 11604064</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Animals ; Biological and medical sciences ; Breathing ; Cancer ; Carbon Dioxide - pharmacology ; General aspects ; Hypoxia ; Imaging ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Miscellaneous. Technology ; Oxygen ; Oxygen - metabolism ; Oxygen - pharmacology ; Oxygen partial pressure ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prostate ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Rats ; Space life sciences ; Tissue oxygenation ; Tumors</subject><ispartof>Radiation research, 2001-11, Vol.156 (5), p.510-520</ispartof><rights>Copyright 2001 The Radiation Research Society</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-520fa249d0fd7f1c4f2f825de2d8115d3e78400d9af488904eb67fc1418dbb183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3580573$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3580573$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14123256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11604064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Dawen</creatorcontrib><creatorcontrib>Constantinescu, Anca</creatorcontrib><creatorcontrib>Hahn, Eric W.</creatorcontrib><creatorcontrib>Mason, Ralph P.</creatorcontrib><title>Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors $(<1\ {\rm cm}^{3})$, the mean $p{\rm O}_{2}$ ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with $p{\rm O}_{2}\ <10$ Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the faster-growing rat prostate tumors investigated previously.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breathing</subject><subject>Cancer</subject><subject>Carbon Dioxide - pharmacology</subject><subject>General aspects</subject><subject>Hypoxia</subject><subject>Imaging</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>Oxygen - pharmacology</subject><subject>Oxygen partial pressure</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Rats</subject><subject>Space life sciences</subject><subject>Tissue oxygenation</subject><subject>Tumors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9rGzEQxUVpaZyk36AUXVqawzqjfytteip2mxgCLsalh1KMvJLsDbuSI2mTGvLhuyRuchrmzW_mDQ-hcwJjUpbyHICxQgolP1MAckZE-RsEgYvlfPprsfxDxzCezL_QV2hEKqYKwYG_RqPnrSN0nNINDD0pq7foiJASOJR8hB6WfRcinv_db6zH073XXVMnfN_kLV7YtLN1xjngyxjuB0V786g2UecQ93iy1W1r_cZe4Jm_syk3G52b4HFwOG8tnvbeN36Df8SQss4WLxijsria4UfbU_TG6TbZd4d6gn5-_7acXBXX88vZ5Ot1UTOqciEoOE15ZcAZ6UjNHXWKCmOpUYQIw6xUHMBU2nGlKuB2XUpXE06UWa-JYifo09PdXQy3_fDmqmtSbdtWexv6tJKUggQGA_jhAPbrzprVLjadjvvV_7wG4OMB0KnWrYva10164TihjIpy4N4_cTdpCOp5zoQCIRn7Bwa8iOU</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Zhao, Dawen</creator><creator>Constantinescu, Anca</creator><creator>Hahn, Eric W.</creator><creator>Mason, Ralph P.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor</title><author>Zhao, Dawen ; Constantinescu, Anca ; Hahn, Eric W. ; Mason, Ralph P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-520fa249d0fd7f1c4f2f825de2d8115d3e78400d9af488904eb67fc1418dbb183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breathing</topic><topic>Cancer</topic><topic>Carbon Dioxide - pharmacology</topic><topic>General aspects</topic><topic>Hypoxia</topic><topic>Imaging</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Oxygen</topic><topic>Oxygen - metabolism</topic><topic>Oxygen - pharmacology</topic><topic>Oxygen partial pressure</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Rats</topic><topic>Space life sciences</topic><topic>Tissue oxygenation</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Dawen</creatorcontrib><creatorcontrib>Constantinescu, Anca</creatorcontrib><creatorcontrib>Hahn, Eric W.</creatorcontrib><creatorcontrib>Mason, Ralph P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Dawen</au><au>Constantinescu, Anca</au><au>Hahn, Eric W.</au><au>Mason, Ralph P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>156</volume><issue>5</issue><spage>510</spage><epage>520</epage><pages>510-520</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors $(<1\ {\rm cm}^{3})$, the mean $p{\rm O}_{2}$ ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with $p{\rm O}_{2}\ <10$ Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the faster-growing rat prostate tumors investigated previously.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>11604064</pmid><doi>10.1667/0033-7587(2001)156[0510:TODWRT]2.0.CO;2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 2001-11, Vol.156 (5), p.510-520 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72207030 |
| source | Jstor Complete Legacy; MEDLINE; BioOne Complete |
| subjects | Animals Biological and medical sciences Breathing Cancer Carbon Dioxide - pharmacology General aspects Hypoxia Imaging Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Miscellaneous. Technology Oxygen Oxygen - metabolism Oxygen - pharmacology Oxygen partial pressure Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prostate Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Rats Space life sciences Tissue oxygenation Tumors |
| title | Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T03%3A46%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tumor%20Oxygen%20Dynamics%20with%20Respect%20to%20Growth%20and%20Respiratory%20Challenge:%20Investigation%20of%20the%20Dunning%20Prostate%20R3327-HI%20Tumor&rft.jtitle=Radiation%20research&rft.au=Zhao,%20Dawen&rft.date=2001-11-01&rft.volume=156&rft.issue=5&rft.spage=510&rft.epage=520&rft.pages=510-520&rft.issn=0033-7587&rft.eissn=1938-5404&rft.coden=RAREAE&rft_id=info:doi/10.1667/0033-7587(2001)156%5B0510:TODWRT%5D2.0.CO;2&rft_dat=%3Cjstor_proqu%3E3580573%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72207030&rft_id=info:pmid/11604064&rft_jstor_id=3580573&rfr_iscdi=true |