Tumor Oxygen Dynamics with Respect to Growth and Respiratory Challenge: Investigation of the Dunning Prostate R3327-HI Tumor

We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing...

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Veröffentlicht in:	Radiation research 2001-11, Vol.156 (5), p.510-520
Hauptverfasser:	Zhao, Dawen, Constantinescu, Anca, Hahn, Eric W., Mason, Ralph P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Breathing Cancer Carbon Dioxide - pharmacology General aspects Hypoxia Imaging Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Miscellaneous. Technology Oxygen Oxygen - metabolism Oxygen - pharmacology Oxygen partial pressure Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prostate Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Rats Space life sciences Tissue oxygenation Tumors
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Zusammenfassung:	We recently described a novel approach to measuring regional tumor oxygen tension using 19 F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors $(
ISSN:	0033-7587 1938-5404
DOI:	10.1667/0033-7587(2001)156[0510:TODWRT]2.0.CO;2