Protein-based inheritance in Saccharomyces cerevisiae: [URE3] as a prion form of the nitrogen regulatory protein Ure2

The [URE3] element of the yeast Saccharomyces cerevisiae results from the presence of an altered form of the nitrogen regulatory protein Ure2. This altered form acts as an infectious protein (prion). Genes affecting [URE3] initiation and propagation should give valuable information about prion disea...

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Veröffentlicht in:	Research in Microbiology 2001-09, Vol.152 (7), p.605-612
1. Verfasser:	Edskes, Herman K.
Format:	Artikel
Sprache:	eng
Schlagworte:	[URE3] element Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Glutathione Peroxidase Growth, nutrition, metabolism, transports, enzymes. Molecular biology Microbiology Mycology Nitrogen - metabolism prion Prions - chemistry Prions - genetics Prions - metabolism Protozoa Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Ure2 nitrogen regulatory protein Ure2 protein Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Beschreibung
Zusammenfassung:	The [URE3] element of the yeast Saccharomyces cerevisiae results from the presence of an altered form of the nitrogen regulatory protein Ure2. This altered form acts as an infectious protein (prion). Genes affecting [URE3] initiation and propagation should give valuable information about prion diseases as well as other conformational diseases.
ISSN:	0923-2508 1769-7123
DOI:	10.1016/S0923-2508(01)01239-6