Practical Ruthenium/Lipase-Catalyzed Asymmetric Transformations of Ketones and Enol Acetates to Chiral Acetates

Practical Ruthenium/Lipase-Catalyzed Asymmetric Transformations of Ketones and Enol Acetates to Chiral Acetates

Ketones were asymmetrically transformed to chiral acetates by one-pot processes using a lipase and an achiral ruthenium complex under 1 atm of hydrogen gas in ethyl acetate. Molecular hydrogen was also effective for the transformation of enol acetates to chiral acetates without additional acyl donor...

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Veröffentlicht in:Organic letters 2000-08, Vol.2 (16), p.2487-2490
Hauptverfasser: Jung, Hyun M, Koh, Jeong H, Kim, Mahn-Joo, Park, Jaiwook
Format: Artikel
Sprache:eng
Schlagworte:
Acetates - chemical synthesis
Acetates - chemistry
Indicators and Reagents
Isomerism
Ketones - chemistry
Lipase
Ruthenium
Structure-Activity Relationship
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Zusammenfassung:Ketones were asymmetrically transformed to chiral acetates by one-pot processes using a lipase and an achiral ruthenium complex under 1 atm of hydrogen gas in ethyl acetate. Molecular hydrogen was also effective for the transformation of enol acetates to chiral acetates without additional acyl donors with the same catalyst system.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006169z