Potent, low molecular weight thrombin receptor antagonists

Potent, low molecular weight thrombin receptor antagonists

Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC 50 of 33 nM. Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h,...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2001-11, Vol.11 (21), p.2851-2853
Hauptverfasser: Chackalamannil, Samuel, Doller, Darı́o, Eagen, Keith, Czarniecki, Michael, Ahn, Ho-Sam, Foster, Carolyn J., Boykow, George
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Medical sciences
Molecular Weight
Pharmacology. Drug treatments
Receptors, Thrombin - antagonists & inhibitors
Structure-Activity Relationship
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Zusammenfassung:Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC 50 of 33 nM. Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC 50 of 33 nM.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00555-8