Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma

An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma...

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Veröffentlicht in:	Cancer letters 2001-10, Vol.172 (1), p.93-98
Hauptverfasser:	Cheung, T H, Lo, K W, Yu, M M, Yim, S F, Poon, C S, Chung, T K, Wong, Y F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Carcinoma - diagnosis Carcinoma - metabolism Carcinoma - virology Cell Cycle Proteins - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - biosynthesis Down-Regulation Female Humans Immunohistochemistry Middle Aged Models, Statistical Papillomaviridae - metabolism Prognosis Regression Analysis Tumor Suppressor Proteins Up-Regulation Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - virology
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