Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma

Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma

An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma...

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Veröffentlicht in:Cancer letters 2001-10, Vol.172 (1), p.93-98
Hauptverfasser: Cheung, T H, Lo, K W, Yu, M M, Yim, S F, Poon, C S, Chung, T K, Wong, Y F
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma - diagnosis
Carcinoma - metabolism
Carcinoma - virology
Cell Cycle Proteins - biosynthesis
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclins - biosynthesis
Down-Regulation
Female
Humans
Immunohistochemistry
Middle Aged
Models, Statistical
Papillomaviridae - metabolism
Prognosis
Regression Analysis
Tumor Suppressor Proteins
Up-Regulation
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - virology
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Zusammenfassung:An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma.
ISSN:0304-3835
DOI:10.1016/S0304-3835(01)00624-3