Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma
An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma...
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| Veröffentlicht in: | Cancer letters 2001-10, Vol.172 (1), p.93-98 |
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| container_title | Cancer letters |
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| creator | Cheung, T H Lo, K W Yu, M M Yim, S F Poon, C S Chung, T K Wong, Y F |
| description | An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma. |
| doi_str_mv | 10.1016/S0304-3835(01)00624-3 |
| format | Article |
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Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma.</description><identifier>ISSN: 0304-3835</identifier><identifier>DOI: 10.1016/S0304-3835(01)00624-3</identifier><identifier>PMID: 11595134</identifier><language>eng</language><publisher>Ireland</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carcinoma - diagnosis ; Carcinoma - metabolism ; Carcinoma - virology ; Cell Cycle Proteins - biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclins - biosynthesis ; Down-Regulation ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Models, Statistical ; Papillomaviridae - metabolism ; Prognosis ; Regression Analysis ; Tumor Suppressor Proteins ; Up-Regulation ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - virology</subject><ispartof>Cancer letters, 2001-10, Vol.172 (1), p.93-98</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11595134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheung, T H</creatorcontrib><creatorcontrib>Lo, K W</creatorcontrib><creatorcontrib>Yu, M M</creatorcontrib><creatorcontrib>Yim, S F</creatorcontrib><creatorcontrib>Poon, C S</creatorcontrib><creatorcontrib>Chung, T K</creatorcontrib><creatorcontrib>Wong, Y F</creatorcontrib><title>Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - virology</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Cyclin-Dependent Kinase Inhibitor p21</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Cyclins - biosynthesis</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Papillomaviridae - metabolism</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Tumor Suppressor Proteins</subject><subject>Up-Regulation</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0304-3835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLAzEUhbNQbK3-BGVW0i7G3pvHpFmWYrVYUFBxOdxJMjAyL5Op6L-3aHV1-A4fBw5jFwjXCJjNn0CATMVCqCngDCDjezpi4_96xE5jfAMAJbU6YSNEZRQKOWabZeFDoHZI_GcffIxV1yZdmfQcp6_LNc5Xm0ecJdS6faWn9z9UtYn14aOyVCeWgq3arqEzdlxSHf35ISfsZX3zvLpLtw-3m9Vym_Yc9JAupMsMQCkXxtnMKul0ZoQirktA540hYR2ZwhMXJXIJqApZZoJDQdpKLybs6ne3D937zschb6pofV1T67tdzDVHg6jFXrw8iLui8S7vQ9VQ-Mr_zotvFoJXPQ</recordid><startdate>20011022</startdate><enddate>20011022</enddate><creator>Cheung, T H</creator><creator>Lo, K W</creator><creator>Yu, M M</creator><creator>Yim, S F</creator><creator>Poon, C S</creator><creator>Chung, T K</creator><creator>Wong, Y F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20011022</creationdate><title>Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma</title><author>Cheung, T H ; Lo, K W ; Yu, M M ; Yim, S F ; Poon, C S ; Chung, T K ; Wong, Y F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-84d6900f489dc6c54d76935a27f01de99a3cda9bea23f124015b4f6320ba7c4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - virology</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Cyclin-Dependent Kinase Inhibitor p21</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Cyclins - biosynthesis</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Papillomaviridae - metabolism</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Tumor Suppressor Proteins</topic><topic>Up-Regulation</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, T H</creatorcontrib><creatorcontrib>Lo, K W</creatorcontrib><creatorcontrib>Yu, M M</creatorcontrib><creatorcontrib>Yim, S F</creatorcontrib><creatorcontrib>Poon, C S</creatorcontrib><creatorcontrib>Chung, T K</creatorcontrib><creatorcontrib>Wong, Y F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, T H</au><au>Lo, K W</au><au>Yu, M M</au><au>Yim, S F</au><au>Poon, C S</au><au>Chung, T K</au><au>Wong, Y F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-10-22</date><risdate>2001</risdate><volume>172</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0304-3835</issn><abstract>An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma.</abstract><cop>Ireland</cop><pmid>11595134</pmid><doi>10.1016/S0304-3835(01)00624-3</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Carcinoma - diagnosis Carcinoma - metabolism Carcinoma - virology Cell Cycle Proteins - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - biosynthesis Down-Regulation Female Humans Immunohistochemistry Middle Aged Models, Statistical Papillomaviridae - metabolism Prognosis Regression Analysis Tumor Suppressor Proteins Up-Regulation Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - virology |
| title | Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma |
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