Spontaneous Deposition of Water-Soluble Substances into Microcapsules: Phenomenon, Mechanism, and Application

Water‐soluble species can be deposited into preformed, multilayered polyelectrolyte capsules, templated onto melamine formaldehyde particles, with high integrity. Efficient encapsulation of albumin within capsules formed from a poly(styrene sulfonate)/poly(allylamine hydrochloride) composite was ach...

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Veröffentlicht in:	Angewandte Chemie International Edition 2002-10, Vol.41 (20), p.3789-3793
Hauptverfasser:	Gao, Changyou, Donath, Edwin, Möhwald, Helmuth, Shen, Jiacong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Biopolymers - pharmacokinetics capsules Capsules - chemical synthesis Capsules - chemistry Colloids Diffusion Drug Carriers - chemical synthesis Drug Carriers - chemistry Humans layered compounds Particle Size polyelectrolytes Polymers self-deposition Serum Albumin - pharmacokinetics Solubility
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Beschreibung
Zusammenfassung:	Water‐soluble species can be deposited into preformed, multilayered polyelectrolyte capsules, templated onto melamine formaldehyde particles, with high integrity. Efficient encapsulation of albumin within capsules formed from a poly(styrene sulfonate)/poly(allylamine hydrochloride) composite was achieved at pH values below the isoelctric point of the protein through spontaneous deposition (see picture).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/1521-3773(20021018)41:20<3789::AID-ANIE3789>3.0.CO;2-D