Error-Prone DNA Polymerases: Novel Structures and the Benefits of Infidelity

Error-Prone DNA Polymerases: Novel Structures and the Benefits of Infidelity

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Cell 2001-10, Vol.107 (1), p.9-12
Hauptverfasser: Friedberg, Errol C., Fischhaber, Paula L., Kisker, Caroline
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Crystallography, X-Ray
DNA Damage
DNA Repair
DNA Replication
DNA-Directed DNA Polymerase - chemistry
DNA-Directed DNA Polymerase - metabolism
Humans
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Protein Structure, Tertiary
Sequence Alignment
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Beschreibung
Zusammenfassung:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(01)00509-8