SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp: II. Structure Elucidation

SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp: II. Structure Elucidation

SW-163C and E are novel antitumor antibiotics, which belong to quinomycin family, isolated from the culture broth of Streptomyces sp. SNA15896. These compounds were determined to be cyclic depsipeptides having 3-hydroxyquinaldic acid as a chromophore and a sulfur-containing intramolecular cross link...

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Veröffentlicht in:Journal of antibiotics 2001/08/25, Vol.54(8), pp.622-627
Hauptverfasser: TAKAHASHI, KOSAKU, KOSHINO, HIROYUKI, ESUMI, YASUAKI, TSUDA, EISUKE, KUROSAWA, KAZUHIKO
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - chemistry
Chemical Phenomena
Chemistry, Physical
Depsipeptides
Echinomycin - analogs & derivatives
Magnetic Resonance Spectroscopy
Molecular Structure
Molecular Weight
Peptides, Cyclic
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry
Streptomyces - metabolism
Sulfur - chemistry
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Zusammenfassung:SW-163C and E are novel antitumor antibiotics, which belong to quinomycin family, isolated from the culture broth of Streptomyces sp. SNA15896. These compounds were determined to be cyclic depsipeptides having 3-hydroxyquinaldic acid as a chromophore and a sulfur-containing intramolecular cross linkage through various spectroscopic analyses.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.622