Adhesion signaling: How β-catenin interacts with its partners

The multi-functional protein β-catenin plays essential roles in cell–cell adhesion and nuclear signaling. Elucidation of the structures of β-catenin complexes is beginning to clarify how β-catenin uses the same surface to bind its various partners, and provides insights into how these interactions m...

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Veröffentlicht in:	Current biology 2001-10, Vol.11 (19), p.R792-R794
Hauptverfasser:	Gottardi, Cara J, Gumbiner, Barry M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Catenin Animals beta Catenin Cadherins - chemistry Cadherins - metabolism Catenins Cell Adhesion - physiology Cell Adhesion Molecules - metabolism Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism HMGB Proteins Phosphoproteins - metabolism Phosphorylation Protein Structure, Tertiary Signal Transduction - physiology TCF Transcription Factors Trans-Activators Transcription Factor 7-Like 1 Protein Transcription Factors - chemistry Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	The multi-functional protein β-catenin plays essential roles in cell–cell adhesion and nuclear signaling. Elucidation of the structures of β-catenin complexes is beginning to clarify how β-catenin uses the same surface to bind its various partners, and provides insights into how these interactions might be regulated.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(01)00473-0