Preparation of Isoprostanes and Neuroprostanes

A new approach to isoprostanes and neuroprostanes featuring cis-dialkyl stereochemistry at the cyclopentane ring has been developed by employing an intramolecular cross-coupling reaction of an alkyl iodide and a tethered alkenylsiloxane for stereoselective installation of a functionalized ω-side cha...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-10, Vol.124 (42), p.12424-12425
Hauptverfasser:	Quan, Long Guo, Cha, Jin Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Chemistry Dinoprost - analogs & derivatives Dinoprost - chemical synthesis Docosahexaenoic Acids - chemical synthesis Exact sciences and technology Isoprostanes - chemical synthesis Medical sciences Neuropharmacology Organic chemistry Pharmacology. Drug treatments Preparations and properties Prostaglandins Stereoisomerism
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Beschreibung
Zusammenfassung:	A new approach to isoprostanes and neuroprostanes featuring cis-dialkyl stereochemistry at the cyclopentane ring has been developed by employing an intramolecular cross-coupling reaction of an alkyl iodide and a tethered alkenylsiloxane for stereoselective installation of a functionalized ω-side chain.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja027451z