Sodium-iodide symporter (NIS)-mediated accumulation of [ 211At]astatide in NIS-transfected human cancer cells

The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [ 211At]astatide in the UVW human glioma cell line transfected to express NIS. [ 211At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [ 131I]iodide uptake. These studies suggest [ 211At]astatide as a possible alternative radionuclide to [ 131I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [ 211At]astatide behavior at a cellular level.