Role of Endogenous Nitric Oxide Generation in the Regulation of Vascular Tone and Reactivity in Small Vessels as Investigated in Transgenic Mice Using Synchrotron Radiation Microangiography

Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays a central role in regulation of vascular tone and reactivity. The purpose of this study is to clarify the basal tone and microvascular reactivity in eNOS-overexpressing transgenic (Tg) mice in vivo with a microangiography system usin...

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Veröffentlicht in:	Nitric oxide 2001-10, Vol.5 (5), p.494-503
Hauptverfasser:	Yamashita, Tomoya, Kawashima, Seinosuke, Ozaki, Masanori, Namiki, Masayuki, Satomi-Kobayashi, Seimi, Seno, Tadashi, Matsuda, Yasuaki, Inoue, Nobutaka, Hirata, Ken-ichi, Akita, Hozuka, Umetani, Keiji, Tanaka, Etsuro, Mori, Hidezo, Yokoyama, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiography - methods Animals Cattle endothelial nitric oxide synthase Enzyme Inhibitors - pharmacology Hindlimb - blood supply Hindlimb - diagnostic imaging In Vitro Techniques Lipopolysaccharides - metabolism Mice Mice, Transgenic microangiography microvascular reactivity Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - physiology Neovascularization, Physiologic NG-Nitroarginine Methyl Ester - pharmacology nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitroprusside - pharmacology Papaverine - pharmacology synchrotron radiation Synchrotrons - instrumentation transgenic mouse vascular tone Vasodilation - drug effects Vasodilator Agents - pharmacology
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Zusammenfassung:	Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays a central role in regulation of vascular tone and reactivity. The purpose of this study is to clarify the basal tone and microvascular reactivity in eNOS-overexpressing transgenic (Tg) mice in vivo with a microangiography system using monochromatic synchrotron radiation (SR). The mouse femoral artery was cannulated, nonionic contrast media was injected, and microangiography was performed in hindlimbs of mice. Serial images of the small blood vessels (diameter
ISSN:	1089-8603 1089-8611
DOI:	10.1006/niox.2001.0376