The dual role of CTLA-4 in Leishmania infection

The role of CTLA-4 in inducing the production of transforming growth factor β (TGF-β) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-β affect T helper cells differently, depending on the maturation. This review discusses the data obtained from d...

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Veröffentlicht in:	Trends in Parasitology 2001-10, Vol.17 (10), p.487-491
Hauptverfasser:	Gomes, Nitza A, DosReis, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antigens, CD Antigens, Differentiation - physiology Biological and medical sciences CD4 + T cells co-stimulation CTLA-4 CTLA-4 Antigen Experimental protozoal diseases and models Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IFN-γ Immunobiology Immunoconjugates immunosuppression Infectious diseases Leishmania Leishmania - pathogenicity Leishmania - physiology Leishmaniasis - immunology Leishmaniasis - physiopathology macrophages Medical sciences Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Parasitic diseases Protozoal diseases T helper lymphocytes T-Lymphocytes, Helper-Inducer - immunology TGF-β Transforming Growth Factor beta - metabolism visceral leishmaniaisis
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Zusammenfassung:	The role of CTLA-4 in inducing the production of transforming growth factor β (TGF-β) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-β affect T helper cells differently, depending on the maturation. This review discusses the data obtained from different experimental models and demonstrates that CTLA-4 is a target molecule for vaccination and therapy against leishmaniasis.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/S1471-4922(01)02038-4