Auditory evoked response during propofol anaesthesia after pre-induction with midazolam
In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients. We compared the auditory evoked responses (AER) in these patie...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2002-08, Vol.89 (2), p.325-327 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Brunner, M.D. Nel, M.R. Fernandes, R. Thornton, C. Newton, D.E.F. |
| description | In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients.
We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam.
LOC, as defined by a loss of response to verbal command and eyelash reflex, occurred after 113 (95% CI, 99–131) s in the control group and 75 (56–101) s in the midazolam group (P |
| doi_str_mv | 10.1093/bja/aef190 |
| format | Article |
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We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam.
LOC, as defined by a loss of response to verbal command and eyelash reflex, occurred after 113 (95% CI, 99–131) s in the control group and 75 (56–101) s in the midazolam group (P<0.05). In the control group 2.3 (2.0–2.6) mg kg−1 propofol caused LOC compared with 1.3 (1.1–1.5) mg kg−1 in the group pretreated with midazolam (P<0.001). Pa amplitude decreased by 60% in the control group and by 54% in the midazolam group while Nb latency increased by 24% in the control group and by 32% in the midazolam group following LOC. These differences were not significant.
We confirmed that coinduction of anaesthesia with midazolam and propofol reduces the requirement of propofol. We also demonstrated that the AER reflects anaesthetic depth rather than plasma concentrations of anaesthetic drugs.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aef190</identifier><identifier>PMID: 12378673</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; anaesthetics i.v ; anaesthetics i.v., propofol ; Anesthesia, General ; Anesthetics, Intravenous ; Anesthetics. Neuromuscular blocking agents ; antagonists benzodiazepine ; antagonists benzodiazepine, midazolam ; Biological and medical sciences ; brain ; brain, evoked potentials ; Confidence Intervals ; Drug Administration Schedule ; evoked potentials ; Evoked Potentials, Auditory - drug effects ; Humans ; Medical sciences ; Midazolam ; Middle Aged ; monitoring ; monitoring, evoked potentials ; Neuropharmacology ; Pharmacology. Drug treatments ; Preanesthetic Medication ; Propofol</subject><ispartof>British journal of anaesthesia : BJA, 2002-08, Vol.89 (2), p.325-327</ispartof><rights>2002 British Journal of Anaesthesia</rights><rights>2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright British Medical Association Aug 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-ee69e6c7c45873005a7118dedd71a60c75a15f8ee8c75884b5964a4670f42e383</citedby><cites>FETCH-LOGICAL-c489t-ee69e6c7c45873005a7118dedd71a60c75a15f8ee8c75884b5964a4670f42e383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13797853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12378673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brunner, M.D.</creatorcontrib><creatorcontrib>Nel, M.R.</creatorcontrib><creatorcontrib>Fernandes, R.</creatorcontrib><creatorcontrib>Thornton, C.</creatorcontrib><creatorcontrib>Newton, D.E.F.</creatorcontrib><title>Auditory evoked response during propofol anaesthesia after pre-induction with midazolam</title><title>British journal of anaesthesia : BJA</title><addtitle>Br. J. Anaesth</addtitle><addtitle>Br. J. Anaesth</addtitle><description>In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients.
We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam.
LOC, as defined by a loss of response to verbal command and eyelash reflex, occurred after 113 (95% CI, 99–131) s in the control group and 75 (56–101) s in the midazolam group (P<0.05). In the control group 2.3 (2.0–2.6) mg kg−1 propofol caused LOC compared with 1.3 (1.1–1.5) mg kg−1 in the group pretreated with midazolam (P<0.001). Pa amplitude decreased by 60% in the control group and by 54% in the midazolam group while Nb latency increased by 24% in the control group and by 32% in the midazolam group following LOC. These differences were not significant.
We confirmed that coinduction of anaesthesia with midazolam and propofol reduces the requirement of propofol. We also demonstrated that the AER reflects anaesthetic depth rather than plasma concentrations of anaesthetic drugs.</description><subject>Adult</subject><subject>anaesthetics i.v</subject><subject>anaesthetics i.v., propofol</subject><subject>Anesthesia, General</subject><subject>Anesthetics, Intravenous</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>antagonists benzodiazepine</subject><subject>antagonists benzodiazepine, midazolam</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>brain, evoked potentials</subject><subject>Confidence Intervals</subject><subject>Drug Administration Schedule</subject><subject>evoked potentials</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Midazolam</subject><subject>Middle Aged</subject><subject>monitoring</subject><subject>monitoring, evoked potentials</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Preanesthetic Medication</subject><subject>Propofol</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90VFr1TAUB_AgDnedvvgBpAj6MKhLmqZJH8dQN7joHibKXsK5yanLXZvUpJ3OT7-MXpyI-JRAfpz_4R9CXjD6ltGWH222cATYsZY-IitWS1Y2UrLHZEUplSVtWbVPnqa0pZTJqhVPyD6ruFSN5Cvy5Xi2bgrxtsCbcI22iJjG4BMWdo7OfyvGGMbQhb4AD5imK0wOCugmjPkJS-ftbCYXfPHDTVfF4Cz8Cj0Mz8heB33C57vzgHx-_-7i5LRcf_pwdnK8Lk2t2qlEbFpsjDS1UJJTKkAypixaKxk01EgBTHQKUeWrUvVGtE0NdSNpV1fIFT8gb5a5ec_vc15QDy4Z7HvwGOakZcVkI1qR4au_4DbM0efdNGulyrVxntHhgkwMKUXs9BjdAPFWM6rvu9a5a710nfHL3cR5M6B9oLtyM3i9A5AM9F0Eb1x6cFzmYPGHC_P4_8BycS5N-PO3hHitc5wU-vTrpa4uz9fnF-Kjvp9bLx7zB9w4jDoZh96gdRHNpG1w_4q5A0QfteY</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Brunner, M.D.</creator><creator>Nel, M.R.</creator><creator>Fernandes, R.</creator><creator>Thornton, C.</creator><creator>Newton, D.E.F.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Auditory evoked response during propofol anaesthesia after pre-induction with midazolam</title><author>Brunner, M.D. ; Nel, M.R. ; Fernandes, R. ; Thornton, C. ; Newton, D.E.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-ee69e6c7c45873005a7118dedd71a60c75a15f8ee8c75884b5964a4670f42e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>anaesthetics i.v</topic><topic>anaesthetics i.v., propofol</topic><topic>Anesthesia, General</topic><topic>Anesthetics, Intravenous</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>antagonists benzodiazepine</topic><topic>antagonists benzodiazepine, midazolam</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>brain, evoked potentials</topic><topic>Confidence Intervals</topic><topic>Drug Administration Schedule</topic><topic>evoked potentials</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Midazolam</topic><topic>Middle Aged</topic><topic>monitoring</topic><topic>monitoring, evoked potentials</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Preanesthetic Medication</topic><topic>Propofol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brunner, M.D.</creatorcontrib><creatorcontrib>Nel, M.R.</creatorcontrib><creatorcontrib>Fernandes, R.</creatorcontrib><creatorcontrib>Thornton, C.</creatorcontrib><creatorcontrib>Newton, D.E.F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brunner, M.D.</au><au>Nel, M.R.</au><au>Fernandes, R.</au><au>Thornton, C.</au><au>Newton, D.E.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auditory evoked response during propofol anaesthesia after pre-induction with midazolam</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br. J. Anaesth</stitle><addtitle>Br. J. Anaesth</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>89</volume><issue>2</issue><spage>325</spage><epage>327</epage><pages>325-327</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients.
We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam.
LOC, as defined by a loss of response to verbal command and eyelash reflex, occurred after 113 (95% CI, 99–131) s in the control group and 75 (56–101) s in the midazolam group (P<0.05). In the control group 2.3 (2.0–2.6) mg kg−1 propofol caused LOC compared with 1.3 (1.1–1.5) mg kg−1 in the group pretreated with midazolam (P<0.001). Pa amplitude decreased by 60% in the control group and by 54% in the midazolam group while Nb latency increased by 24% in the control group and by 32% in the midazolam group following LOC. These differences were not significant.
We confirmed that coinduction of anaesthesia with midazolam and propofol reduces the requirement of propofol. We also demonstrated that the AER reflects anaesthetic depth rather than plasma concentrations of anaesthetic drugs.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12378673</pmid><doi>10.1093/bja/aef190</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult anaesthetics i.v anaesthetics i.v., propofol Anesthesia, General Anesthetics, Intravenous Anesthetics. Neuromuscular blocking agents antagonists benzodiazepine antagonists benzodiazepine, midazolam Biological and medical sciences brain brain, evoked potentials Confidence Intervals Drug Administration Schedule evoked potentials Evoked Potentials, Auditory - drug effects Humans Medical sciences Midazolam Middle Aged monitoring monitoring, evoked potentials Neuropharmacology Pharmacology. Drug treatments Preanesthetic Medication Propofol |
| title | Auditory evoked response during propofol anaesthesia after pre-induction with midazolam |
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