Auditory evoked response during propofol anaesthesia after pre-induction with midazolam

In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients. We compared the auditory evoked responses (AER) in these patie...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2002-08, Vol.89 (2), p.325-327
Hauptverfasser:	Brunner, M.D., Nel, M.R., Fernandes, R., Thornton, C., Newton, D.E.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult anaesthetics i.v anaesthetics i.v., propofol Anesthesia, General Anesthetics, Intravenous Anesthetics. Neuromuscular blocking agents antagonists benzodiazepine antagonists benzodiazepine, midazolam Biological and medical sciences brain brain, evoked potentials Confidence Intervals Drug Administration Schedule evoked potentials Evoked Potentials, Auditory - drug effects Humans Medical sciences Midazolam Middle Aged monitoring monitoring, evoked potentials Neuropharmacology Pharmacology. Drug treatments Preanesthetic Medication Propofol
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Zusammenfassung:	In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients. We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam. LOC, as defined by a loss of response to verbal command and eyelash reflex, occurred after 113 (95% CI, 99–131) s in the control group and 75 (56–101) s in the midazolam group (P
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/aef190