Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with Type II diabetes

We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Myocardial blood flow was assessed by positron emission tomography...

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Veröffentlicht in:	Diabetologia 2002-10, Vol.45 (10), p.1404-1409
Hauptverfasser:	IOZZO, P, CHAREONTHAITAWEE, P, RIMOLDI, O, BETTERIDGE, D. J, CAMICI, P. G, FERRANNINI, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Flow Velocity - drug effects Blood Glucose - metabolism Body Mass Index Coronary Circulation - drug effects Coronary Circulation - physiology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Glucose Clamp Technique Heart - drug effects Heart - physiology Heart - physiopathology Humans Hyperinsulinism - blood Hyperinsulinism - physiopathology Insulin - administration & dosage Insulin - pharmacology Male Medical sciences Middle Aged Myocardium - metabolism Patient Selection Reference Values Regional Blood Flow - drug effects
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Zusammenfassung:	We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Myocardial blood flow was assessed by positron emission tomography with oxygen-15 labelled water (H(2)(15)O) either before or after 1 h of euglycaemic hyperinsulinaemia. Myocardial glucose uptake was assessed by positron emission tomography and fluorine-18 labelled fluorodeoxyglucose ((18)FDG). During hyperinsulinaemia, myocardial blood flow increased from 0.91+/-0.03 to 1.00+/-0.03 ml(.)min(-1.)g(-1) in control subjects ( p
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-002-0917-3