Cytogenetic analysis of primary neuroblastoma with del(1), del(14), hsr, and dmin chromosomes

The results of a direct cytogenetic tumor analysis in a 2 1 2 -year-old girl with metastatic neuroblastoma are presented in this paper. Investigations established a modal karyotype of 46 chromosomes with several marker chromosomes. Besides del(1)(p31), hsr, and dmin chromosomes in all the cells anal...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1991-09, Vol.55 (2), p.231-234
Hauptverfasser:	PETKOVIC, I, CEPULIC, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Neoplasms - genetics Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - secondary Child, Preschool Chromosome Deletion Chromosomes, Human, Pair 14 Female Humans Karyotyping Medical sciences Neuroblastoma - genetics Neuroblastoma - secondary Neurology Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	The results of a direct cytogenetic tumor analysis in a 2 1 2 -year-old girl with metastatic neuroblastoma are presented in this paper. Investigations established a modal karyotype of 46 chromosomes with several marker chromosomes. Besides del(1)(p31), hsr, and dmin chromosomes in all the cells analyzed, terminal deletion of the long arm of chromosome 14 was also identified. Malignant cells were thus monosomic for segment 14q24→qter.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(91)90082-6