Pregnancy Outcomes of Patients Who Conceived within 1 Year after Chemotherapy for Gestational Trophoblastic Tumor: A Clinical Report of 22 Patients

Objective. The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). Methods. From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed...

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Veröffentlicht in:Gynecologic oncology 2001-10, Vol.83 (1), p.146-148
Hauptverfasser: Lan, Zhu, Hongzhao, Song, Xiuyu, Yang, Yang, Xiang
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container_title Gynecologic oncology
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creator Lan, Zhu
Hongzhao, Song
Xiuyu, Yang
Yang, Xiang
description Objective. The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). Methods. From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed retrospectively. Results. Among 22 patients, 9 had term deliveries and 1 had a premature birth, 6 had induced abortion at the patient's request, and 6 had therapeutic abortion because of various indications such as repeated hydatidiform mole (1 case), intrauterine death (1 case), inevitable abortion (1 case), and threatened abortion (3 cases). The fetal loss rate was 27.1% (6/22). The incidence rate of gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence rate of GTT was 4.5% (1/22). The average interval between completion of chemotherapy and pregnancy was 10.25 months in the group of term pregnancies and 5.86 months in that of fetal loss (P < 0.05), indicating that the longer the interval, the lesser the risk of GTD. Conclusion. The results suggest that contraception for 1 year is necessary in patients with GTT after successful chemotherapy. However, in the case of a patient who conceives within 1 year, it is not necessary to terminate pregnancy, but the pregnancy must be carefully watched.
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The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). Methods. From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed retrospectively. Results. Among 22 patients, 9 had term deliveries and 1 had a premature birth, 6 had induced abortion at the patient's request, and 6 had therapeutic abortion because of various indications such as repeated hydatidiform mole (1 case), intrauterine death (1 case), inevitable abortion (1 case), and threatened abortion (3 cases). The fetal loss rate was 27.1% (6/22). The incidence rate of gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence rate of GTT was 4.5% (1/22). The average interval between completion of chemotherapy and pregnancy was 10.25 months in the group of term pregnancies and 5.86 months in that of fetal loss (P &lt; 0.05), indicating that the longer the interval, the lesser the risk of GTD. Conclusion. The results suggest that contraception for 1 year is necessary in patients with GTT after successful chemotherapy. However, in the case of a patient who conceives within 1 year, it is not necessary to terminate pregnancy, but the pregnancy must be carefully watched.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.2001.6170</identifier><identifier>PMID: 11585428</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; chemotherapy ; Choriocarcinoma - drug therapy ; Choriocarcinoma - pathology ; Female ; Female genital diseases ; gestational trophoblastic tumor (GTT) ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Neoplasm Staging ; Pregnancy ; Pregnancy Outcome ; Trophoblastic Neoplasms - drug therapy ; Trophoblastic Neoplasms - pathology ; Tropical medicine ; Tumors ; Uterine Neoplasms - drug therapy ; Uterine Neoplasms - pathology</subject><ispartof>Gynecologic oncology, 2001-10, Vol.83 (1), p.146-148</ispartof><rights>2001 Academic Press</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-1a7a6260f1bd5cac5d8ca880ba1e3e0d48f62018dd0c2c67697b654164f86f8a3</citedby><cites>FETCH-LOGICAL-c370t-1a7a6260f1bd5cac5d8ca880ba1e3e0d48f62018dd0c2c67697b654164f86f8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825801961700$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14124059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11585428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lan, Zhu</creatorcontrib><creatorcontrib>Hongzhao, Song</creatorcontrib><creatorcontrib>Xiuyu, Yang</creatorcontrib><creatorcontrib>Yang, Xiang</creatorcontrib><title>Pregnancy Outcomes of Patients Who Conceived within 1 Year after Chemotherapy for Gestational Trophoblastic Tumor: A Clinical Report of 22 Patients</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Objective. The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). Methods. From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed retrospectively. Results. Among 22 patients, 9 had term deliveries and 1 had a premature birth, 6 had induced abortion at the patient's request, and 6 had therapeutic abortion because of various indications such as repeated hydatidiform mole (1 case), intrauterine death (1 case), inevitable abortion (1 case), and threatened abortion (3 cases). The fetal loss rate was 27.1% (6/22). The incidence rate of gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence rate of GTT was 4.5% (1/22). The average interval between completion of chemotherapy and pregnancy was 10.25 months in the group of term pregnancies and 5.86 months in that of fetal loss (P &lt; 0.05), indicating that the longer the interval, the lesser the risk of GTD. Conclusion. The results suggest that contraception for 1 year is necessary in patients with GTT after successful chemotherapy. However, in the case of a patient who conceives within 1 year, it is not necessary to terminate pregnancy, but the pregnancy must be carefully watched.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>chemotherapy</subject><subject>Choriocarcinoma - drug therapy</subject><subject>Choriocarcinoma - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>gestational trophoblastic tumor (GTT)</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Trophoblastic Neoplasms - drug therapy</subject><subject>Trophoblastic Neoplasms - pathology</subject><subject>Tropical medicine</subject><subject>Tumors</subject><subject>Uterine Neoplasms - drug therapy</subject><subject>Uterine Neoplasms - pathology</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EokvhyhH5ArcsY2_iONyqCApSpVZoEeJkOc64MUrixXaK9nfwh3G0K3riNId55kPvQ8hrBlsGIN7fH2e_5QBsK1gNT8iGQVMVQlbNU7IBaKCQvJIX5EWMPwFgB4w_JxeMVbIqudyQP3cB72c9myO9XZLxE0bqLb3TyeGcIv0-eNr62aB7wJ7-dmlwM2X0B-pAtU0YaDvg5NOAQR-O1PpArzGmPO5nPdJ98IfBd6OOyRm6XyYfPtAr2o5udib3v-LBh7Re5Pzf0ZfkmdVjxFfnekm-ffq4bz8XN7fXX9qrm8LsakgF07UWXIBlXV8ZbapeGi0ldJrhDqEvpRUcmOx7MNyIWjR1J6qSidJKYaXeXZJ3p72H4H8t-Ws1uWhwHPWMfomq5qwuQdQZ3J5AE3yMAa06BDfpcFQM1KpBrRrUqkGtGvLAm_PmpZuwf8TPuWfg7RnQMedgQzbg4iNXMl5C1WROnjjMOTw4DCqanJHB3gU0SfXe_e-Hv_7vpVA</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Lan, Zhu</creator><creator>Hongzhao, Song</creator><creator>Xiuyu, Yang</creator><creator>Yang, Xiang</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Pregnancy Outcomes of Patients Who Conceived within 1 Year after Chemotherapy for Gestational Trophoblastic Tumor: A Clinical Report of 22 Patients</title><author>Lan, Zhu ; Hongzhao, Song ; Xiuyu, Yang ; Yang, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-1a7a6260f1bd5cac5d8ca880ba1e3e0d48f62018dd0c2c67697b654164f86f8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>chemotherapy</topic><topic>Choriocarcinoma - drug therapy</topic><topic>Choriocarcinoma - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>gestational trophoblastic tumor (GTT)</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Trophoblastic Neoplasms - drug therapy</topic><topic>Trophoblastic Neoplasms - pathology</topic><topic>Tropical medicine</topic><topic>Tumors</topic><topic>Uterine Neoplasms - drug therapy</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lan, Zhu</creatorcontrib><creatorcontrib>Hongzhao, Song</creatorcontrib><creatorcontrib>Xiuyu, Yang</creatorcontrib><creatorcontrib>Yang, Xiang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lan, Zhu</au><au>Hongzhao, Song</au><au>Xiuyu, Yang</au><au>Yang, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy Outcomes of Patients Who Conceived within 1 Year after Chemotherapy for Gestational Trophoblastic Tumor: A Clinical Report of 22 Patients</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>83</volume><issue>1</issue><spage>146</spage><epage>148</epage><pages>146-148</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>Objective. The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). Methods. From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed retrospectively. Results. Among 22 patients, 9 had term deliveries and 1 had a premature birth, 6 had induced abortion at the patient's request, and 6 had therapeutic abortion because of various indications such as repeated hydatidiform mole (1 case), intrauterine death (1 case), inevitable abortion (1 case), and threatened abortion (3 cases). The fetal loss rate was 27.1% (6/22). The incidence rate of gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence rate of GTT was 4.5% (1/22). The average interval between completion of chemotherapy and pregnancy was 10.25 months in the group of term pregnancies and 5.86 months in that of fetal loss (P &lt; 0.05), indicating that the longer the interval, the lesser the risk of GTD. Conclusion. The results suggest that contraception for 1 year is necessary in patients with GTT after successful chemotherapy. However, in the case of a patient who conceives within 1 year, it is not necessary to terminate pregnancy, but the pregnancy must be carefully watched.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>11585428</pmid><doi>10.1006/gyno.2001.6170</doi><tpages>3</tpages></addata></record>
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subjects Adult
Biological and medical sciences
chemotherapy
Choriocarcinoma - drug therapy
Choriocarcinoma - pathology
Female
Female genital diseases
gestational trophoblastic tumor (GTT)
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Neoplasm Staging
Pregnancy
Pregnancy Outcome
Trophoblastic Neoplasms - drug therapy
Trophoblastic Neoplasms - pathology
Tropical medicine
Tumors
Uterine Neoplasms - drug therapy
Uterine Neoplasms - pathology
title Pregnancy Outcomes of Patients Who Conceived within 1 Year after Chemotherapy for Gestational Trophoblastic Tumor: A Clinical Report of 22 Patients
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