Cerebrospinal Fluid Penetration of Levofloxacin in Patients with Spontaneous Acute Bacterial Meningitis

We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (CL/CP) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99 ± 0.67 μg/mL, and the CL/CP at 2 hours afte...

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Veröffentlicht in:	Clinical infectious diseases 2001-11, Vol.33 (9), p.e109-e111
Hauptverfasser:	Scotton, P. G., Pea, F., Giobbia, M., Baraldo, M., Vaglia, A., Furlanut, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Anti-Infective Agents - cerebrospinal fluid Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - therapeutic use Female Humans Levofloxacin Male Meningitis, Escherichia coli - cerebrospinal fluid Meningitis, Escherichia coli - drug therapy Meningitis, Meningococcal - cerebrospinal fluid Meningitis, Meningococcal - drug therapy Meningitis, Pneumococcal - cerebrospinal fluid Meningitis, Pneumococcal - drug therapy Middle Aged Ofloxacin - cerebrospinal fluid Ofloxacin - pharmacokinetics Ofloxacin - therapeutic use
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Zusammenfassung:	We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (CL/CP) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99 ± 0.67 μg/mL, and the CL/CP at 2 hours after dosing was 0.34 ± 0.09.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/323406