A Novel Three-Component Reaction for the Diastereoselective Synthesis of 2H-Pyrimido[2,1-a]isoquinolines via 1,4-Dipolar Cycloaddition

A Novel Three-Component Reaction for the Diastereoselective Synthesis of 2H-Pyrimido[2,1-a]isoquinolines via 1,4-Dipolar Cycloaddition

The 1,4-dipole derived from isoquinoline and DMAD has been shown to react readily with N-tosylimines resulting in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives.

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Veröffentlicht in:Organic letters 2002-10, Vol.4 (21), p.3575-3577
Hauptverfasser: Nair, Vijay, Sreekanth, A. R, Abhilash, N, Bhadbhade, Mohan M, Gonnade, Rajesh C
Format: Artikel
Sprache:eng
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Zusammenfassung:The 1,4-dipole derived from isoquinoline and DMAD has been shown to react readily with N-tosylimines resulting in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0264004