BCR-ABL insufficiency for the transformation of human stem cells into CML

On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency.

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Bibliographische Detailangaben
Veröffentlicht in:	Medical hypotheses 2002-11, Vol.59 (5), p.588-589
1. Verfasser:	Matioli, G.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cell Transformation, Neoplastic - genetics Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - physiology Granulocytes - pathology Hematopoietic Stem Cells - pathology Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - etiology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Models, Biological Neoplastic Stem Cells - pathology Reference Values
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Beschreibung
Zusammenfassung:	On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/S0306-9877(02)00220-7