APPLICATION OF POLYMERASE CHAIN REACTION (PCR) TO HLA-C LOCUS TYPING

APPLICATION OF POLYMERASE CHAIN REACTION (PCR) TO HLA-C LOCUS TYPING

SUMMARY Polymerase chain reaction/oligonucleotide typing was used to identify HLA‐Cw*0601 (Cw6) in patients with psoriasis and psoriatic arthritis. The assignment of HLA‐Cw*0601 was established by the concordant presence of codons for alanine (position 73), lysine (position 80) and tryptophan (posit...

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Veröffentlicht in:European journal of immunogenetics 1991-06, Vol.18 (3), p.185-187
Hauptverfasser: Sakkas, L. I., Vaughan, R. W., Panayi, G. S., Welsh, K. I.
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis, Psoriatic - immunology
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
HLA-C Antigens - genetics
Humans
Immunophenotyping
Molecular immunology
Molecular Sequence Data
Oligonucleotide Probes - genetics
Polymerase Chain Reaction
Psoriasis - immunology
Techniques
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Zusammenfassung:SUMMARY Polymerase chain reaction/oligonucleotide typing was used to identify HLA‐Cw*0601 (Cw6) in patients with psoriasis and psoriatic arthritis. The assignment of HLA‐Cw*0601 was established by the concordant presence of codons for alanine (position 73), lysine (position 80) and tryptophan (position 97). The frequencies of all three codons were increased in the patient groups.
ISSN:1744-3121
0960-7420
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.1991.tb00018.x