Exiguamide, a new spirocyclic sesquiterpene from the marine sponge Geodia exigua that inhibits cell fate specification during sea urchin embryogenesis

A new nitrogen-containing bicyclic spirosesquiterpene designated exiguamide which inhibited cell fate specification during sea urchin embryogenesis has been isolated from the marine sponge Geodia exigua. Its structure was determined by interpretation of spectral data and X-ray crystallographic analy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-11, Vol.12 (21), p.3037-3039
Hauptverfasser:	Uy, Mylene M, Ohta, Shinji, Yanai, Mihoko, Ohta, Emi, Hirata, Toshifumi, Ikegami, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Crystallography, X-Ray Embryo, Nonmammalian - cytology Embryo, Nonmammalian - drug effects Embryonic Development Larva Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Ovum - cytology Ovum - drug effects Ovum - growth & development Porifera - chemistry Sea Urchins Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology
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Zusammenfassung:	A new nitrogen-containing bicyclic spirosesquiterpene designated exiguamide which inhibited cell fate specification during sea urchin embryogenesis has been isolated from the marine sponge Geodia exigua. Its structure was determined by interpretation of spectral data and X-ray crystallographic analysis. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)00662-5