New anti-MRSA and anti-VRE carbapenems; synthesis and structure-activity relationships of 1beta-methyl-2-(thiazol-2-ylthio)carbapenems

Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against methicillin-resistant staphylococci, vancomycin-resis...

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Veröffentlicht in:Journal of antibiotics 2002-08, Vol.55 (8), p.722-757
Hauptverfasser: Sunagawa, Makoto, Itoh, Masanori, Kubota, Katsumi, Sasaki, Akira, Ueda, Yutaka, Angehrn, Peter, Bourson, Anne, Goetschi, Erwin, Hebeisen, Paul, Then, Rudolf L
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Sprache:eng
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Zusammenfassung:Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant Streptococcus pneumoniae, a series of 1beta-methylcarbapenems with thiazol-2-ylthio groups at the C-2 position have been synthesized. Structure-activity relationships were investigated which led to SM-197436 (27), SM-232721 (44) and SM-232724 (41), being selected for further evaluation.
ISSN:0021-8820