Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases
To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms. DNA samples from patients with a range of...
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| Veröffentlicht in: | AIDS (London) 2002-10, Vol.16 (15), p.2043-2047 |
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| creator | PRICE, Patricia MORAHAN, Grant DEXING HUANG STONE, Emma CHEONG, Karey Y. M CASTLEY, Alison RODGERS, Marina MCINTYRE, Meredith Q ABRAHAM, Lawrence J FRENCH, Martyn A |
| description | To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms.
DNA samples from patients with a range of IRD were typed for polymorphic loci in genes encoding immune-mediators.
PCR-restriction fragment length polymorphism assays were used to type loci in the and genes. Alleles of a microsatellite in the CD30 promoter were determined by capillary electrophoresis.
Only 8% of patients with IRD associated with a herpesvirus infection carried IL12B-3'UTR*2, compared with 42-54% of patients with other or no IRD. Patients with IRD arising from mycobacterial infection rarely carried IL6-174*C (36% versus 61-71%) and never carried TNFA-308*2 (0% versus 23-52%). TNFA-308*2 was carried by 52% of patients who experienced IRD associated with a herpesvirus infection, as several patients with exacerbations of cytomegalovirus retinitis carried this as part of a HLA-A2,B44 haplotype. Polymorphisms in and showed no distinct patterns.
Distinct cytokine-mediated mechanisms contribute to IRD initiated by herpesvirus and mycobacterial infections. |
| doi_str_mv | 10.1097/00002030-200210180-00009 |
| format | Article |
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DNA samples from patients with a range of IRD were typed for polymorphic loci in genes encoding immune-mediators.
PCR-restriction fragment length polymorphism assays were used to type loci in the and genes. Alleles of a microsatellite in the CD30 promoter were determined by capillary electrophoresis.
Only 8% of patients with IRD associated with a herpesvirus infection carried IL12B-3'UTR*2, compared with 42-54% of patients with other or no IRD. Patients with IRD arising from mycobacterial infection rarely carried IL6-174*C (36% versus 61-71%) and never carried TNFA-308*2 (0% versus 23-52%). TNFA-308*2 was carried by 52% of patients who experienced IRD associated with a herpesvirus infection, as several patients with exacerbations of cytomegalovirus retinitis carried this as part of a HLA-A2,B44 haplotype. Polymorphisms in and showed no distinct patterns.
Distinct cytokine-mediated mechanisms contribute to IRD initiated by herpesvirus and mycobacterial infections.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200210180-00009</identifier><identifier>PMID: 12370503</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; AIDS-Related Opportunistic Infections - genetics ; AIDS-Related Opportunistic Infections - immunology ; AIDS/HIV ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; Cytokines - genetics ; Cytomegalovirus Retinitis - genetics ; Cytomegalovirus Retinitis - immunology ; Encephalomyelitis - genetics ; Encephalomyelitis - immunology ; Genetic Predisposition to Disease ; HIV Infections - complications ; HIV-1 ; Human viral diseases ; Humans ; Immune System ; Infectious diseases ; Medical sciences ; Mycobacterium avium-intracellulare Infection - genetics ; Mycobacterium avium-intracellulare Infection - immunology ; Polymorphism, Genetic ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2002-10, Vol.16 (15), p.2043-2047</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-ad957b4097500601d2516630a4f3a6c5cf0fff1e29c95691e8753a1359194e303</citedby><cites>FETCH-LOGICAL-c422t-ad957b4097500601d2516630a4f3a6c5cf0fff1e29c95691e8753a1359194e303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14023592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12370503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PRICE, Patricia</creatorcontrib><creatorcontrib>MORAHAN, Grant</creatorcontrib><creatorcontrib>DEXING HUANG</creatorcontrib><creatorcontrib>STONE, Emma</creatorcontrib><creatorcontrib>CHEONG, Karey Y. M</creatorcontrib><creatorcontrib>CASTLEY, Alison</creatorcontrib><creatorcontrib>RODGERS, Marina</creatorcontrib><creatorcontrib>MCINTYRE, Meredith Q</creatorcontrib><creatorcontrib>ABRAHAM, Lawrence J</creatorcontrib><creatorcontrib>FRENCH, Martyn A</creatorcontrib><title>Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms.
DNA samples from patients with a range of IRD were typed for polymorphic loci in genes encoding immune-mediators.
PCR-restriction fragment length polymorphism assays were used to type loci in the and genes. Alleles of a microsatellite in the CD30 promoter were determined by capillary electrophoresis.
Only 8% of patients with IRD associated with a herpesvirus infection carried IL12B-3'UTR*2, compared with 42-54% of patients with other or no IRD. Patients with IRD arising from mycobacterial infection rarely carried IL6-174*C (36% versus 61-71%) and never carried TNFA-308*2 (0% versus 23-52%). TNFA-308*2 was carried by 52% of patients who experienced IRD associated with a herpesvirus infection, as several patients with exacerbations of cytomegalovirus retinitis carried this as part of a HLA-A2,B44 haplotype. Polymorphisms in and showed no distinct patterns.
Distinct cytokine-mediated mechanisms contribute to IRD initiated by herpesvirus and mycobacterial infections.</description><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - genetics</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS/HIV</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biological and medical sciences</subject><subject>Cytokines - genetics</subject><subject>Cytomegalovirus Retinitis - genetics</subject><subject>Cytomegalovirus Retinitis - immunology</subject><subject>Encephalomyelitis - genetics</subject><subject>Encephalomyelitis - immunology</subject><subject>Genetic Predisposition to Disease</subject><subject>HIV Infections - complications</subject><subject>HIV-1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune System</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mycobacterium avium-intracellulare Infection - genetics</subject><subject>Mycobacterium avium-intracellulare Infection - immunology</subject><subject>Polymorphism, Genetic</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhLyBf4BaYseMkPqKK0kqV4ABcI68zpoYkDp5EsP8eb7vQI3MZzdP3xh49ISTCGwTbvoVSCjRUqnQE7KA6SvaR2GHd6sqYFh-LHajGVla3cCaeMX8vhIGueyrOUBXRgN4J_pTGw5Tycht5Yhln6Q9r-hFnkt9oJpYDhePA235Jyza6NaaZZQry6vprhXIpAs0ry1-3SdLvhXIZPQ0yTtNWfJl4TfnOJYfI5Jj4uXgS3Mj04tTPxZfL958vrqqbjx-uL97dVL5Waq3cYE27r8u9BqABHJTBptHg6qBd440PEEJAUtZb01ikrjXaoTYWbU0a9Ll4fb93yennVj7ST5E9jaObKW3ctwpNbbX6L4hdowDrpoDdPehzYs4U-iXHyeVDj9Afk-n_JtP_S-ZOssX68vTGtp9oeDCeoijAqxPg2LsxZDf7yA9cDaqcpvQflueWfw</recordid><startdate>20021018</startdate><enddate>20021018</enddate><creator>PRICE, Patricia</creator><creator>MORAHAN, Grant</creator><creator>DEXING HUANG</creator><creator>STONE, Emma</creator><creator>CHEONG, Karey Y. M</creator><creator>CASTLEY, Alison</creator><creator>RODGERS, Marina</creator><creator>MCINTYRE, Meredith Q</creator><creator>ABRAHAM, Lawrence J</creator><creator>FRENCH, Martyn A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021018</creationdate><title>Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases</title><author>PRICE, Patricia ; MORAHAN, Grant ; DEXING HUANG ; STONE, Emma ; CHEONG, Karey Y. M ; CASTLEY, Alison ; RODGERS, Marina ; MCINTYRE, Meredith Q ; ABRAHAM, Lawrence J ; FRENCH, Martyn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-ad957b4097500601d2516630a4f3a6c5cf0fff1e29c95691e8753a1359194e303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>AIDS-Related Opportunistic Infections - genetics</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS/HIV</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biological and medical sciences</topic><topic>Cytokines - genetics</topic><topic>Cytomegalovirus Retinitis - genetics</topic><topic>Cytomegalovirus Retinitis - immunology</topic><topic>Encephalomyelitis - genetics</topic><topic>Encephalomyelitis - immunology</topic><topic>Genetic Predisposition to Disease</topic><topic>HIV Infections - complications</topic><topic>HIV-1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immune System</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mycobacterium avium-intracellulare Infection - genetics</topic><topic>Mycobacterium avium-intracellulare Infection - immunology</topic><topic>Polymorphism, Genetic</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRICE, Patricia</creatorcontrib><creatorcontrib>MORAHAN, Grant</creatorcontrib><creatorcontrib>DEXING HUANG</creatorcontrib><creatorcontrib>STONE, Emma</creatorcontrib><creatorcontrib>CHEONG, Karey Y. M</creatorcontrib><creatorcontrib>CASTLEY, Alison</creatorcontrib><creatorcontrib>RODGERS, Marina</creatorcontrib><creatorcontrib>MCINTYRE, Meredith Q</creatorcontrib><creatorcontrib>ABRAHAM, Lawrence J</creatorcontrib><creatorcontrib>FRENCH, Martyn A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PRICE, Patricia</au><au>MORAHAN, Grant</au><au>DEXING HUANG</au><au>STONE, Emma</au><au>CHEONG, Karey Y. M</au><au>CASTLEY, Alison</au><au>RODGERS, Marina</au><au>MCINTYRE, Meredith Q</au><au>ABRAHAM, Lawrence J</au><au>FRENCH, Martyn A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2002-10-18</date><risdate>2002</risdate><volume>16</volume><issue>15</issue><spage>2043</spage><epage>2047</epage><pages>2043-2047</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms.
DNA samples from patients with a range of IRD were typed for polymorphic loci in genes encoding immune-mediators.
PCR-restriction fragment length polymorphism assays were used to type loci in the and genes. Alleles of a microsatellite in the CD30 promoter were determined by capillary electrophoresis.
Only 8% of patients with IRD associated with a herpesvirus infection carried IL12B-3'UTR*2, compared with 42-54% of patients with other or no IRD. Patients with IRD arising from mycobacterial infection rarely carried IL6-174*C (36% versus 61-71%) and never carried TNFA-308*2 (0% versus 23-52%). TNFA-308*2 was carried by 52% of patients who experienced IRD associated with a herpesvirus infection, as several patients with exacerbations of cytomegalovirus retinitis carried this as part of a HLA-A2,B44 haplotype. Polymorphisms in and showed no distinct patterns.
Distinct cytokine-mediated mechanisms contribute to IRD initiated by herpesvirus and mycobacterial infections.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12370503</pmid><doi>10.1097/00002030-200210180-00009</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2002-10, Vol.16 (15), p.2043-2047 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72154932 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult AIDS-Related Opportunistic Infections - genetics AIDS-Related Opportunistic Infections - immunology AIDS/HIV Antiretroviral Therapy, Highly Active Biological and medical sciences Cytokines - genetics Cytomegalovirus Retinitis - genetics Cytomegalovirus Retinitis - immunology Encephalomyelitis - genetics Encephalomyelitis - immunology Genetic Predisposition to Disease HIV Infections - complications HIV-1 Human viral diseases Humans Immune System Infectious diseases Medical sciences Mycobacterium avium-intracellulare Infection - genetics Mycobacterium avium-intracellulare Infection - immunology Polymorphism, Genetic Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases |
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