Bone Marrow Transplantation for Sickle Cell Disease: A Study of Parents' Decisions

BONE marrow transplantation is the only therapy that has been reported to cure patients with sickle cell disease. 1 2 3 However, when performed for currently accepted indications, this procedure is associated with a 10 to 50 percent risk of mortality and substantial additional risk of morbidity due...

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Veröffentlicht in:The New England journal of medicine 1991-11, Vol.325 (19), p.1349-1353
Hauptverfasser: Kodish, Eric, Lantos, John, Stocking, Carol, Singer, Peter A, Siegler, Mark, Johnson, F. Leonard
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Sprache:eng
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Zusammenfassung:BONE marrow transplantation is the only therapy that has been reported to cure patients with sickle cell disease. 1 2 3 However, when performed for currently accepted indications, this procedure is associated with a 10 to 50 percent risk of mortality and substantial additional risk of morbidity due to graft-versus-host disease (GVHD). 4 5 6 7 8 The mortality and morbidity have been readily accepted when bone marrow transplantation is used for life-threatening diseases, such as leukemia, for which no better treatment is available. But is this treatment appropriate for diseases that are not immediately life-threatening, such as sickle cell disease? Sickle cell disease has an extremely variable . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199111073251905