Bone Marrow Transplantation for Sickle Cell Disease: A Study of Parents' Decisions
BONE marrow transplantation is the only therapy that has been reported to cure patients with sickle cell disease. 1 2 3 However, when performed for currently accepted indications, this procedure is associated with a 10 to 50 percent risk of mortality and substantial additional risk of morbidity due...
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Veröffentlicht in: | The New England journal of medicine 1991-11, Vol.325 (19), p.1349-1353 |
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Zusammenfassung: | BONE marrow transplantation is the only therapy that has been reported to cure patients with sickle cell disease.
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However, when performed for currently accepted indications, this procedure is associated with a 10 to 50 percent risk of mortality and substantial additional risk of morbidity due to graft-versus-host disease (GVHD).
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The mortality and morbidity have been readily accepted when bone marrow transplantation is used for life-threatening diseases, such as leukemia, for which no better treatment is available. But is this treatment appropriate for diseases that are not immediately life-threatening, such as sickle cell disease?
Sickle cell disease has an extremely variable . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM199111073251905 |