Water-Soluble Oligomer Dimers Based on Paracyclophane:  A New Optical Platform for Fluorescent Sensor Applications

Water-Soluble Oligomer Dimers Based on Paracyclophane:  A New Optical Platform for Fluorescent Sensor Applications

Water soluble paracyclophane chromophore dimers provide optical reporters that show little sensitivity to surfactants and thus are ideal for biosensor design. Strong intramolecular delocalization circumvents complications from intermolecular delocalization in spontaneously formed aggregates. The syn...

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Veröffentlicht in:Journal of the American Chemical Society 2002-10, Vol.124 (40), p.11868-11869
Hauptverfasser: Hong, Janice W, Gaylord, Brent S, Bazan, Guillermo C
Format: Artikel
Sprache:eng
Schlagworte:
Biosensing Techniques - methods
Bridged-Ring Compounds - chemistry
Ethers - chemistry
Fluorescent Dyes - chemistry
Light
Polymers - chemistry
Quaternary Ammonium Compounds - chemistry
Scattering, Radiation
Solubility
Spectrometry, Fluorescence - methods
Surface-Active Agents - chemistry
Water - chemistry
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Zusammenfassung:Water soluble paracyclophane chromophore dimers provide optical reporters that show little sensitivity to surfactants and thus are ideal for biosensor design. Strong intramolecular delocalization circumvents complications from intermolecular delocalization in spontaneously formed aggregates. The synthesis of 2 involves a novel TBAT deprotection/butane sultone ring-opening sequence, which should be general for the preparation of water-soluble conjugated oligomers and polymers.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja027170r