Hemodynamic and Humoral Effects of Vasopeptidase Inhibition in Canine Hypertension

ABSTRACT—Vasopeptidase inhibitors are potent new antihypertensive agents. The dual inhibition of ACE and neutral endopeptidase may result in synergistic humoral effects with unique hemodynamic actions. We investigated the hemodynamic and neurohumoral effects of vasopeptidase inhibition in conscious...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-10, Vol.40 (4), p.528-534
Hauptverfasser:	Maniu, Calin V, Meyer, Donna M, Redfield, Margaret M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Angiotensin II - antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive agents Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Atrial Natriuretic Factor - blood Biological and medical sciences Cardiovascular system Dogs Fosinopril - administration & dosage Fosinopril - pharmacology Fosinopril - therapeutic use Hemodynamics - drug effects Hypertension - blood Hypertension - drug therapy Hypertension - enzymology Hypertension - physiopathology Kinetics Male Medical sciences Neprilysin - antagonists & inhibitors Peptides - blood Peptides - pharmacology Pharmacology. Drug treatments Protease Inhibitors - administration & dosage Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Pyridines - administration & dosage Pyridines - pharmacology Pyridines - therapeutic use Thiazepines - administration & dosage Thiazepines - pharmacology Thiazepines - therapeutic use Vasoconstrictor Agents - antagonists & inhibitors
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Zusammenfassung:	ABSTRACT—Vasopeptidase inhibitors are potent new antihypertensive agents. The dual inhibition of ACE and neutral endopeptidase may result in synergistic humoral effects with unique hemodynamic actions. We investigated the hemodynamic and neurohumoral effects of vasopeptidase inhibition in conscious dogs made hypertensive by bilateral renal wrapping and subsequently instrumented for long-term assessment of left ventricular pressure and volume (n=8). Intravenous vasopeptidase inhibition (omapatrilat, 30 μmol/kg over 10 minutes) reduced peak left ventricular pressure (171±6 versus 130±6 mm Hg immediately after infusion, P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000033223.17484.B1