Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties

Several sulfonamides containing pyrroles ( 2a– c, 6a– d, 8a– d), pyrrolo[2,3-d] pyrimidines ( 3a– c), acetanilides ( 11a– c) and tetrahydrobenzothiophenes ( 13a– c) were synthesized starting from N 4-chloroacetylsulfanilamides ( 1a– d). The structures of synthesized compounds were elucidated by elem...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2002-08, Vol.57 (8), p.613-617
Hauptverfasser:	El-Gaby, M.S.A., Gaber, A.M., Atalla, A.A., Abd Al-Wahab, K.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Fungi - drug effects Medical sciences Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Pyrrole Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology Pyrrolo[2,3-d]pyrimidine benzothiophene derivatives Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several sulfonamides containing pyrroles ( 2a– c, 6a– d, 8a– d), pyrrolo[2,3-d] pyrimidines ( 3a– c), acetanilides ( 11a– c) and tetrahydrobenzothiophenes ( 13a– c) were synthesized starting from N 4-chloroacetylsulfanilamides ( 1a– d). The structures of synthesized compounds were elucidated by elemental analyses and spectral data. Compounds 2b, 3b, 6b, 8b and 8d exhibited a remarkable antifungal activity compared with the standard fungicide mycostatine.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(01)01178-8