A Readily-Accessible (+)-Sparteine Surrogate

A Readily-Accessible (+)-Sparteine Surrogate

A “(+)-sparteine-like” chiral diamine, readily synthesized in three steps from (−)-cytisine, has been evaluated in four different asymmetric transformations; in each case, selectivity in an enantiocomplementary fashion to (−)-sparteine was observed.

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Veröffentlicht in:Journal of the American Chemical Society 2002-10, Vol.124 (40), p.11870-11871
Hauptverfasser: Dearden, Michael J, Firkin, Catherine R, Hermet, Jean-Paul R, O'Brien, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemistry
Alkaloids - isolation & purification
Azocines
Diamines - chemical synthesis
Diamines - chemistry
Molecular Mimicry
Pyridones - chemical synthesis
Pyridones - chemistry
Quinolizines
Sparteine - analogs & derivatives
Sparteine - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:A “(+)-sparteine-like” chiral diamine, readily synthesized in three steps from (−)-cytisine, has been evaluated in four different asymmetric transformations; in each case, selectivity in an enantiocomplementary fashion to (−)-sparteine was observed.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja027774v