Oral sumatriptan in acute migraine

The efficacy in acute migraine of oral sumatriptan was assessed in a double-blind, randomised, placebo-controlled, crossover study of 61 patients (mean age 39 [SD 10] years). 41 completed treatment of four attacks, two with sumatriptan 100 mg and two with placebo. The response rate (reduction in hea...

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Veröffentlicht in:	The Lancet (British edition) 1991-09, Vol.338 (8770), p.782-783
Hauptverfasser:	Goadsby, P.J., Zagami, A.S., Anthony, M., Lance, J.W., Donnan, G.A., Bladin, P.F., Symington, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Oral Adolescent Adult Biological and medical sciences Crossovers Double-Blind Method Drug Evaluation Drugs Female Headache Headaches Humans Indoles - administration & dosage Indoles - therapeutic use Male Medical research Medical sciences Middle Aged Migraine Migraine Disorders - drug therapy Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Patients Pharmacology. Drug treatments Recurrence Serotoninergic system Side effects Sulfonamides - administration & dosage Sulfonamides - therapeutic use Sumatriptan Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - therapeutic use
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Zusammenfassung:	The efficacy in acute migraine of oral sumatriptan was assessed in a double-blind, randomised, placebo-controlled, crossover study of 61 patients (mean age 39 [SD 10] years). 41 completed treatment of four attacks, two with sumatriptan 100 mg and two with placebo. The response rate (reduction in headache from moderate or severe to mild or absent at 2 h) was 51% (45/89) with sumatriptan and 10% (9/93) with placebo (p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/0140-6736(91)90666-D