Effect of morning versus evening intake of simvastatin on the serum cholesterol level in patients with coronary artery disease

Simvastatin had a better effect on total and low-density lipoprotein cholesterol when morning and evening dose regimens were compared, whereas no difference in high-density lipoprotein cholesterol, triglycerides, or high, sensitive C-reactive protein was demonstrated in this crossover study.

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Bibliographische Detailangaben
Veröffentlicht in:	The American journal of cardiology 2002-10, Vol.90 (7), p.784-786
Hauptverfasser:	Lund, Tor M, Torsvik, Harald, Falch, Dagfinn, Christophersen, B.jørn, Skårdal, Rita, Gullestad, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticholesteremic Agents - administration & dosage Biological and medical sciences C-Reactive Protein - metabolism Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Circadian Rhythm Coronary Artery Disease - blood Coronary Artery Disease - drug therapy Cross-Over Studies Drug Administration Schedule Drug therapy Female General and cellular metabolism. Vitamins Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Proteins Simvastatin - administration & dosage Treatment Outcome Triglycerides - blood
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Beschreibung
Zusammenfassung:	Simvastatin had a better effect on total and low-density lipoprotein cholesterol when morning and evening dose regimens were compared, whereas no difference in high-density lipoprotein cholesterol, triglycerides, or high, sensitive C-reactive protein was demonstrated in this crossover study.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(02)02614-0