Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells

After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2002-09, Vol.17 (3), p.329-339
Hauptverfasser:	Toyama, Hirochika, Okada, Seiji, Hatano, Masahiko, Takahashi, Yoshimasa, Takeda, Nobue, Ichii, Hirohito, Takemori, Toshitada, Kuroda, Yoshikazu, Tokuhisa, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals B-Lymphocyte Subsets - immunology Bone Marrow - immunology Bone Marrow Cells - cytology Bone Marrow Cells - immunology Cell Differentiation Cell Lineage DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Rearrangement, B-Lymphocyte, Heavy Chain Genes Genes, Immunoglobulin Germinal Center - cytology Germinal Center - immunology Homeodomain Proteins - genetics Immune system Immunization Immunoglobulin Class Switching Immunoglobulin G - biosynthesis Immunoglobulin Heavy Chains - genetics Immunoglobulin M - biosynthesis Immunoglobulin Variable Region - genetics Immunoglobulins Immunologic Memory - genetics Mice Mice, Inbred C57BL Mice, Knockout Mutation Organ Specificity Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-6 Radiation Chimera Rodents Somatic Hypermutation, Immunoglobulin Specific Pathogen-Free Organisms Spleen - cytology Spleen - immunology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology
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