Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells
After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl...
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Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2002-09, Vol.17 (3), p.329-339 |
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Sprache: | eng |
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Zusammenfassung: | After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the spleen but barely differentiated into long-lived IgG1 antibody-forming cells in the bone marrow. Mutation in the
V-heavy gene was null in these memory B cells. Therefore, Bcl6 and germinal center formation are essential for somatic hypermutation, and generation of memory B cells can occur independently of germinal center formation, somatic hypermutation, and Ig class switching. |
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ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/S1074-7613(02)00387-4 |