Stereoselective Synthesis of a Novel Apio Analogue of Neplanocin A as Potential S-Adenosylhomocysteine Hydrolase Inhibitor

A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potential inhibitor of S-adenosylhomocysteine hydrolase, was accomplished starting from d-ribose via stereoselective hydroxymethylation and RCM reaction.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2002-10, Vol.4 (20), p.3501-3503
Hauptverfasser:	Moon, Hyung Ryong, Kim, Hea Ok, Lee, Kang Man, Chun, Moon Woo, Kim, Joong Hyup, Jeong, Lak Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - chemical synthesis Adenosine - chemistry Adenosylhomocysteinase Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Hydrolases - antagonists & inhibitors Molecular Structure Stereoisomerism
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Beschreibung
Zusammenfassung:	A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potential inhibitor of S-adenosylhomocysteine hydrolase, was accomplished starting from d-ribose via stereoselective hydroxymethylation and RCM reaction.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol026624m