Diazonamide Synthesis Studies: Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2002-10, Vol.4 (20), p.3525-3528
Hauptverfasser:	Feldman, Ken S, Eastman, Kyle J, Lessene, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Molecular Structure Oxazoles - chemical synthesis Oxazoles - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol026694t