Retinoic acid signaling at sites of plasticity in the mature central nervous system
We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a d...
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Veröffentlicht in: | Journal of comparative neurology (1911) 2002-10, Vol.452 (3), p.228-241 |
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description | We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228–241, 2002. © 2002 Wiley‐Liss, Inc. |
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We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228–241, 2002. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.10369</identifier><identifier>PMID: 12353219</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aldehyde Oxidoreductases - biosynthesis ; Aldehyde Oxidoreductases - genetics ; amygdala ; Animals ; Calbindin 2 ; Calbindins ; cortex ; Gene Expression Regulation ; Genes, Reporter ; habenula ; interneuron ; Male ; Mice ; Mice, Transgenic ; Neuronal Plasticity - genetics ; Neurons - metabolism ; olfactory bulb ; Olfactory Bulb - cytology ; Olfactory Bulb - metabolism ; plasticity ; Proto-Oncogene Proteins c-fos - biosynthesis ; Proto-Oncogene Proteins c-fos - genetics ; Receptors, Retinoic Acid - biosynthesis ; Receptors, Retinoic Acid - genetics ; Retinal Dehydrogenase ; retinoic acid ; Retinoic Acid Receptor alpha ; Retinoid X Receptors ; S100 Calcium Binding Protein G - biosynthesis ; S100 Calcium Binding Protein G - genetics ; Signal Transduction - genetics ; spinal cord ; Spinal Cord - cytology ; Spinal Cord - metabolism ; Transcription Factors - biosynthesis ; Transcription Factors - genetics ; Tretinoin - metabolism</subject><ispartof>Journal of comparative neurology (1911), 2002-10, Vol.452 (3), p.228-241</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3059-aedc078fa86d844df545823c1fac87a10cbd89ac97f43c941c8c37fcec257e6f3</citedby><cites>FETCH-LOGICAL-c3059-aedc078fa86d844df545823c1fac87a10cbd89ac97f43c941c8c37fcec257e6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.10369$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.10369$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12353219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson Haskell, Gloria</creatorcontrib><creatorcontrib>Maynard, Thomas Michael</creatorcontrib><creatorcontrib>Shatzmiller, Ron Andrew</creatorcontrib><creatorcontrib>Lamantia, Anthony-Samuel</creatorcontrib><title>Retinoic acid signaling at sites of plasticity in the mature central nervous system</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228–241, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Aldehyde Oxidoreductases - biosynthesis</subject><subject>Aldehyde Oxidoreductases - genetics</subject><subject>amygdala</subject><subject>Animals</subject><subject>Calbindin 2</subject><subject>Calbindins</subject><subject>cortex</subject><subject>Gene Expression Regulation</subject><subject>Genes, Reporter</subject><subject>habenula</subject><subject>interneuron</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neurons - metabolism</subject><subject>olfactory bulb</subject><subject>Olfactory Bulb - cytology</subject><subject>Olfactory Bulb - metabolism</subject><subject>plasticity</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Receptors, Retinoic Acid - biosynthesis</subject><subject>Receptors, Retinoic Acid - genetics</subject><subject>Retinal Dehydrogenase</subject><subject>retinoic acid</subject><subject>Retinoic Acid Receptor alpha</subject><subject>Retinoid X Receptors</subject><subject>S100 Calcium Binding Protein G - biosynthesis</subject><subject>S100 Calcium Binding Protein G - genetics</subject><subject>Signal Transduction - genetics</subject><subject>spinal cord</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - metabolism</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - genetics</subject><subject>Tretinoin - metabolism</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2KqgTaQ_8A8gmphwV7vbu2jyiiAQmCCkUcLTM7Bpf9SG2nkH9fQ9JyQpxmRvPMq9FDyFfODjhj5SEMmBvR6A9kwpluCq0avkUmeccLrRu5TXZi_MUY01qoT2Sbl6IWJdcTcnWJyQ-jB2rBtzT6u8F2frijNuUhYaSjo4vOxuTBpxX1A033SHublgEp4JCC7eiA4c-4jDSuYsL-M_nobBfxy6bukuvvxz-nJ8XZxex0enRWgGC1Liy2wKRyVjWtqqrW1VWtSgHcWVDScga3rdIWtHSVAF1xUCCkA4Syltg4sUv217mLMP5eYkym9xGw6-yA-RsjS55Jpt4Fuaq1VmWTwW9rEMIYY0BnFsH3NqwMZ-ZZtcmqzYvqzO5tQpe3Pbav5MZtBg7XwKPvcPV2kpnOj_9FFusLnzU-_b-w4cE0Usja3Mxn5oSzczX_MTNS_AX06JgY</recordid><startdate>20021021</startdate><enddate>20021021</enddate><creator>Thompson Haskell, Gloria</creator><creator>Maynard, Thomas Michael</creator><creator>Shatzmiller, Ron Andrew</creator><creator>Lamantia, Anthony-Samuel</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20021021</creationdate><title>Retinoic acid signaling at sites of plasticity in the mature central nervous system</title><author>Thompson Haskell, Gloria ; Maynard, Thomas Michael ; Shatzmiller, Ron Andrew ; Lamantia, Anthony-Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3059-aedc078fa86d844df545823c1fac87a10cbd89ac97f43c941c8c37fcec257e6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aldehyde Oxidoreductases - biosynthesis</topic><topic>Aldehyde Oxidoreductases - genetics</topic><topic>amygdala</topic><topic>Animals</topic><topic>Calbindin 2</topic><topic>Calbindins</topic><topic>cortex</topic><topic>Gene Expression Regulation</topic><topic>Genes, Reporter</topic><topic>habenula</topic><topic>interneuron</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neurons - metabolism</topic><topic>olfactory bulb</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - metabolism</topic><topic>plasticity</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Receptors, Retinoic Acid - biosynthesis</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Retinal Dehydrogenase</topic><topic>retinoic acid</topic><topic>Retinoic Acid Receptor alpha</topic><topic>Retinoid X Receptors</topic><topic>S100 Calcium Binding Protein G - biosynthesis</topic><topic>S100 Calcium Binding Protein G - genetics</topic><topic>Signal Transduction - genetics</topic><topic>spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - metabolism</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><topic>Tretinoin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson Haskell, Gloria</creatorcontrib><creatorcontrib>Maynard, Thomas Michael</creatorcontrib><creatorcontrib>Shatzmiller, Ron Andrew</creatorcontrib><creatorcontrib>Lamantia, Anthony-Samuel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson Haskell, Gloria</au><au>Maynard, Thomas Michael</au><au>Shatzmiller, Ron Andrew</au><au>Lamantia, Anthony-Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid signaling at sites of plasticity in the mature central nervous system</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2002-10-21</date><risdate>2002</risdate><volume>452</volume><issue>3</issue><spage>228</spage><epage>241</epage><pages>228-241</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228–241, 2002. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12353219</pmid><doi>10.1002/cne.10369</doi><tpages>14</tpages></addata></record> |
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subjects | Aldehyde Oxidoreductases - biosynthesis Aldehyde Oxidoreductases - genetics amygdala Animals Calbindin 2 Calbindins cortex Gene Expression Regulation Genes, Reporter habenula interneuron Male Mice Mice, Transgenic Neuronal Plasticity - genetics Neurons - metabolism olfactory bulb Olfactory Bulb - cytology Olfactory Bulb - metabolism plasticity Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics Receptors, Retinoic Acid - biosynthesis Receptors, Retinoic Acid - genetics Retinal Dehydrogenase retinoic acid Retinoic Acid Receptor alpha Retinoid X Receptors S100 Calcium Binding Protein G - biosynthesis S100 Calcium Binding Protein G - genetics Signal Transduction - genetics spinal cord Spinal Cord - cytology Spinal Cord - metabolism Transcription Factors - biosynthesis Transcription Factors - genetics Tretinoin - metabolism |
title | Retinoic acid signaling at sites of plasticity in the mature central nervous system |
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