Retinoic acid signaling at sites of plasticity in the mature central nervous system

We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a d...

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Veröffentlicht in:Journal of comparative neurology (1911) 2002-10, Vol.452 (3), p.228-241
Hauptverfasser: Thompson Haskell, Gloria, Maynard, Thomas Michael, Shatzmiller, Ron Andrew, Lamantia, Anthony-Samuel
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container_title Journal of comparative neurology (1911)
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creator Thompson Haskell, Gloria
Maynard, Thomas Michael
Shatzmiller, Ron Andrew
Lamantia, Anthony-Samuel
description We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228–241, 2002. © 2002 Wiley‐Liss, Inc.
doi_str_mv 10.1002/cne.10369
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We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. 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Comp. Neurol</addtitle><description>We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5‐RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5‐RARE transgene‐expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain—the established source for newly generated granule and periglomerular neurons. In addition, there are transgene‐labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA‐mediated gene expression, detected with the DR5‐RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells—particularly those in the spinal cord and olfactory bulb—are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. 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Maynard, Thomas Michael ; Shatzmiller, Ron Andrew ; Lamantia, Anthony-Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3059-aedc078fa86d844df545823c1fac87a10cbd89ac97f43c941c8c37fcec257e6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aldehyde Oxidoreductases - biosynthesis</topic><topic>Aldehyde Oxidoreductases - genetics</topic><topic>amygdala</topic><topic>Animals</topic><topic>Calbindin 2</topic><topic>Calbindins</topic><topic>cortex</topic><topic>Gene Expression Regulation</topic><topic>Genes, Reporter</topic><topic>habenula</topic><topic>interneuron</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neurons - metabolism</topic><topic>olfactory bulb</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - metabolism</topic><topic>plasticity</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Receptors, Retinoic Acid - biosynthesis</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Retinal Dehydrogenase</topic><topic>retinoic acid</topic><topic>Retinoic Acid Receptor alpha</topic><topic>Retinoid X Receptors</topic><topic>S100 Calcium Binding Protein G - biosynthesis</topic><topic>S100 Calcium Binding Protein G - genetics</topic><topic>Signal Transduction - genetics</topic><topic>spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - metabolism</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><topic>Tretinoin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson Haskell, Gloria</creatorcontrib><creatorcontrib>Maynard, Thomas Michael</creatorcontrib><creatorcontrib>Shatzmiller, Ron Andrew</creatorcontrib><creatorcontrib>Lamantia, Anthony-Samuel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson Haskell, Gloria</au><au>Maynard, Thomas Michael</au><au>Shatzmiller, Ron Andrew</au><au>Lamantia, Anthony-Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid signaling at sites of plasticity in the mature central nervous system</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. 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subjects Aldehyde Oxidoreductases - biosynthesis
Aldehyde Oxidoreductases - genetics
amygdala
Animals
Calbindin 2
Calbindins
cortex
Gene Expression Regulation
Genes, Reporter
habenula
interneuron
Male
Mice
Mice, Transgenic
Neuronal Plasticity - genetics
Neurons - metabolism
olfactory bulb
Olfactory Bulb - cytology
Olfactory Bulb - metabolism
plasticity
Proto-Oncogene Proteins c-fos - biosynthesis
Proto-Oncogene Proteins c-fos - genetics
Receptors, Retinoic Acid - biosynthesis
Receptors, Retinoic Acid - genetics
Retinal Dehydrogenase
retinoic acid
Retinoic Acid Receptor alpha
Retinoid X Receptors
S100 Calcium Binding Protein G - biosynthesis
S100 Calcium Binding Protein G - genetics
Signal Transduction - genetics
spinal cord
Spinal Cord - cytology
Spinal Cord - metabolism
Transcription Factors - biosynthesis
Transcription Factors - genetics
Tretinoin - metabolism
title Retinoic acid signaling at sites of plasticity in the mature central nervous system
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