Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats

Infusion of the 5-HT 1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5–20 μg in 1 μ1 during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plas...

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Veröffentlicht in:	European journal of pharmacology 1991-05, Vol.197 (2), p.225-228
Hauptverfasser:	Korte, S.Mechiel, Van Duin, Solita, Bouws, Gerdien A.H., Koolhaas, Jaap M., Bohus, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 1A receptors 8-Hydroxy-2-(di-n-propylamino)tetralin Adrenal Medulla - physiology Adrenaline Animals Biological and medical sciences Corticosterone Corticosterone - blood Epinephrine - blood Fundamental and applied biological sciences. Psychology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Hypothalamo-Hypophyseal System - physiology Male Norepinephrine - blood Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiology Paraventricular nucleus Pituitary-Adrenal System - physiology Rats Rats, Inbred Strains Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Serotonin - physiology Sympathetic Nervous System - physiology Tetrahydronaphthalenes - administration & dosage Tetrahydronaphthalenes - pharmacology Vertebrates: endocrinology
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Zusammenfassung:	Infusion of the 5-HT 1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5–20 μg in 1 μ1 during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitaryadrenocortical axis are activated after stimulation of 5-HT 1A receptors in the PVN.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90527-W