Heterogeneity in human soluble guanylate cyclase due to alternative splicing
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published parti...
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| Veröffentlicht in: | FEBS letters 1991-09, Vol.290 (1), p.157-158 |
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| creator | Chhajlani, Vijay Frändberg, Per-Anders Ahlner, Johan Axelsson, Krister L. Wikberg, Jarl E.S. |
| description | Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing. |
| doi_str_mv | 10.1016/0014-5793(91)81248-7 |
| format | Article |
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One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(91)81248-7</identifier><identifier>PMID: 1680753</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alternative splicing ; Animals ; Base Sequence ; Biological and medical sciences ; Cattle ; Fundamental and applied biological sciences. Psychology ; Guanylate Cyclase - chemistry ; Guanylate Cyclase - genetics ; Human guanylate cyclase ; Humans ; Molecular and cellular biology ; Molecular genetics ; Oligonucleotides - chemistry ; Polymerase Chain Reaction ; Polymerase chain Reaction, cDNA ; Rats ; RNA Splicing ; Sequence Alignment ; Solubility ; Transcription. Transcription factor. Splicing. Rna processing</subject><ispartof>FEBS letters, 1991-09, Vol.290 (1), p.157-158</ispartof><rights>1991</rights><rights>FEBS Letters 290 (1991) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4497-74ba44e0f6b24962632c4044590311c5a2dd18fffeda2378bd90efe90fbc42df3</citedby><cites>FETCH-LOGICAL-c4497-74ba44e0f6b24962632c4044590311c5a2dd18fffeda2378bd90efe90fbc42df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579391812487$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4990369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1680753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chhajlani, Vijay</creatorcontrib><creatorcontrib>Frändberg, Per-Anders</creatorcontrib><creatorcontrib>Ahlner, Johan</creatorcontrib><creatorcontrib>Axelsson, Krister L.</creatorcontrib><creatorcontrib>Wikberg, Jarl E.S.</creatorcontrib><title>Heterogeneity in human soluble guanylate cyclase due to alternative splicing</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.</description><subject>Alternative splicing</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate Cyclase - chemistry</subject><subject>Guanylate Cyclase - genetics</subject><subject>Human guanylate cyclase</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Oligonucleotides - chemistry</subject><subject>Polymerase Chain Reaction</subject><subject>Polymerase chain Reaction, cDNA</subject><subject>Rats</subject><subject>RNA Splicing</subject><subject>Sequence Alignment</subject><subject>Solubility</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vFCEYx4nR1LX2G2jCwTR6GAWGHYZLk9p0rckmXuyZMPCwpWGZFWbWzLeX6WzqzXgiPP8XeH4IvaPkMyW0-UII5dVayPqjpJ9aynhbiRdoRVtRVzVv2pdo9Wx5jd7k_EjKvaXyDJ3RpiViXa_Q9g4GSP0OIvhhwj7ih3GvI859GLsAeDfqOAU9ADaTCToDtiPgocc6lFzUgz8CzofgjY-7t-iV0yHDxek8R_eb2583d9X2x7fvN9fbynAuRSV4pzkH4pqOcdmwpmaGE87XktSUmrVm1tLWOQdWs1q0nZUEHEjiOsOZdfU5ulx6D6n_NUIe1N5nAyHoCP2YlWCFBidNMfLFaFKfcwKnDsnvdZoUJWqGqGZCaiakJFVPEJUosfen_rHbg_0bWqgV_cNJ19no4JKOxudnG5dlkUYW22ax_fYBpv96Wm1uv7JZmOeSPk3n_1wtRVCgHj0klY2HaMD6BGZQtvf_XugPNvahQg</recordid><startdate>19910923</startdate><enddate>19910923</enddate><creator>Chhajlani, Vijay</creator><creator>Frändberg, Per-Anders</creator><creator>Ahlner, Johan</creator><creator>Axelsson, Krister L.</creator><creator>Wikberg, Jarl E.S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910923</creationdate><title>Heterogeneity in human soluble guanylate cyclase due to alternative splicing</title><author>Chhajlani, Vijay ; Frändberg, Per-Anders ; Ahlner, Johan ; Axelsson, Krister L. ; Wikberg, Jarl E.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4497-74ba44e0f6b24962632c4044590311c5a2dd18fffeda2378bd90efe90fbc42df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alternative splicing</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanylate Cyclase - chemistry</topic><topic>Guanylate Cyclase - genetics</topic><topic>Human guanylate cyclase</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Oligonucleotides - chemistry</topic><topic>Polymerase Chain Reaction</topic><topic>Polymerase chain Reaction, cDNA</topic><topic>Rats</topic><topic>RNA Splicing</topic><topic>Sequence Alignment</topic><topic>Solubility</topic><topic>Transcription. Transcription factor. Splicing. 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One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1680753</pmid><doi>10.1016/0014-5793(91)81248-7</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1991-09, Vol.290 (1), p.157-158 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72124406 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alternative splicing Animals Base Sequence Biological and medical sciences Cattle Fundamental and applied biological sciences. Psychology Guanylate Cyclase - chemistry Guanylate Cyclase - genetics Human guanylate cyclase Humans Molecular and cellular biology Molecular genetics Oligonucleotides - chemistry Polymerase Chain Reaction Polymerase chain Reaction, cDNA Rats RNA Splicing Sequence Alignment Solubility Transcription. Transcription factor. Splicing. Rna processing |
| title | Heterogeneity in human soluble guanylate cyclase due to alternative splicing |
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