Heterogeneity in human soluble guanylate cyclase due to alternative splicing

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published parti...

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Veröffentlicht in:	FEBS letters 1991-09, Vol.290 (1), p.157-158
Hauptverfasser:	Chhajlani, Vijay, Frändberg, Per-Anders, Ahlner, Johan, Axelsson, Krister L., Wikberg, Jarl E.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Base Sequence Biological and medical sciences Cattle Fundamental and applied biological sciences. Psychology Guanylate Cyclase - chemistry Guanylate Cyclase - genetics Human guanylate cyclase Humans Molecular and cellular biology Molecular genetics Oligonucleotides - chemistry Polymerase Chain Reaction Polymerase chain Reaction, cDNA Rats RNA Splicing Sequence Alignment Solubility Transcription. Transcription factor. Splicing. Rna processing
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Beschreibung
Zusammenfassung:	Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(91)81248-7