Reduction of salbutamol-induced drinking by putative and proven antidepressants

Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration...

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Veröffentlicht in:European journal of pharmacology 1991-05, Vol.197 (2), p.217-219
Hauptverfasser: Gard, Paul R., Fawcett, J.Paul, Kerr, Karen P.
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container_title European journal of pharmacology
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creator Gard, Paul R.
Fawcett, J.Paul
Kerr, Karen P.
description Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration of the drugs resulted in a significant reduction in the salbutamol-induced fluid intake. The results suggest that these drugs decrease β 2-adrenoceptor activity, but that repeated administration is not a prerequisite for the effect.
doi_str_mv 10.1016/0014-2999(91)90525-U
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subjects Albuterol - administration & dosage
Albuterol - antagonists & inhibitors
Albuterol - pharmacology
Animals
Antidepressive agents
Antidepressive Agents - administration & dosage
Antidepressive Agents - pharmacology
Biological and medical sciences
Clenbuterol - pharmacology
Desipramine - pharmacology
Drinking Behavior - drug effects
Drinking Behavior - physiology
Drinking behaviour
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Receptors, Adrenergic, beta - drug effects
Receptors, Adrenergic, beta - physiology
β-Adrenoceptor agonists
β-Adrenoceptors
title Reduction of salbutamol-induced drinking by putative and proven antidepressants
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