Reduction of salbutamol-induced drinking by putative and proven antidepressants

Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration...

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Veröffentlicht in:	European journal of pharmacology 1991-05, Vol.197 (2), p.217-219
Hauptverfasser:	Gard, Paul R., Fawcett, J.Paul, Kerr, Karen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuterol - administration & dosage Albuterol - antagonists & inhibitors Albuterol - pharmacology Animals Antidepressive agents Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Biological and medical sciences Clenbuterol - pharmacology Desipramine - pharmacology Drinking Behavior - drug effects Drinking Behavior - physiology Drinking behaviour Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - physiology β-Adrenoceptor agonists β-Adrenoceptors
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Zusammenfassung:	Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration of the drugs resulted in a significant reduction in the salbutamol-induced fluid intake. The results suggest that these drugs decrease β 2-adrenoceptor activity, but that repeated administration is not a prerequisite for the effect.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90525-U