Possible involvement of nitric oxide in long-term potentiation

Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We...

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Veröffentlicht in:	European journal of pharmacology 1991-07, Vol.199 (3), p.379-381
Hauptverfasser:	Böhme, Georg A., Bon, Christelle, Stutzmann, Jean-Marie, Doble, Adam, Blanchard, Jean-Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology Hippocampus (rat) Hippocampus - drug effects Hippocampus - physiology Long-term potentiation Male Neuronal Plasticity - physiology Nitric oxide (NO) Nitric Oxide - metabolism Nitroarginine Nitroprusside - pharmacology Rats Rats, Inbred Strains Synapses - drug effects Synapses - physiology Synaptic plasticity Vertebrates: nervous system and sense organs
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Zusammenfassung:	Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We report here that the NO-synthase inhibitor, L-Nω-nitroarginine, blocks LTP and that sodium nitroprusside, which releases NO, produces a long-lasting enhancement in synaptic efficacy which is not additive with tetanus-induced LTP.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90505-K