Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)

Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)

6-(2-Dimethylaminonaphthoyl) alanine (DANA) was prepared via an enantioselective synthesis and incorporated into the S-peptide of RNase S establishing the large changes in fluorescence that can occur upon peptide-protein interaction.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2002-09 (17), p.1912-1913
Hauptverfasser: Nitz, Mark, Mezo, Adam R, Ali, Mayssam H, Imperiali, Barbara
Format: Artikel
Sprache:eng
Schlagworte:
Alanine - analogs & derivatives
Alanine - chemical synthesis
Alanine - chemistry
Amino Acid Sequence
Fluorescence
Molecular Sequence Data
Molecular Structure
Naphthalenes - chemical synthesis
Naphthalenes - chemistry
Peptides - chemistry
Ribonucleases - chemistry
Spectrometry, Fluorescence
Stereoisomerism
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Beschreibung
Zusammenfassung:6-(2-Dimethylaminonaphthoyl) alanine (DANA) was prepared via an enantioselective synthesis and incorporated into the S-peptide of RNase S establishing the large changes in fluorescence that can occur upon peptide-protein interaction.
ISSN:1359-7345
DOI:10.1039/b205224e