T-Cell Depletion of HLA-Identical Transplants in Leukemia

T-Cell Depletion of HLA-Identical Transplants in Leukemia

We analyzed the effects of T-cell depletion on the outcome of HLA-identical sibling bone marrow transplants for leukemia by comparing 731 T-cell-depleted transplants with 2,480 non-T-cell-depleted transplants. T-cell depletion decreased acute graft-versus-host disease (GVHD) (relative risk [RR] 0.45...

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Veröffentlicht in:Blood 1991-10, Vol.78 (8), p.2120-2130
Hauptverfasser: Marmont, Alberto M., Horowitz, Mary M., Gale, Robert Peter, Sobocinski, Kathleen, Ash, Robert C., van Bekkum, Dirk W., Champlin, Richard E., Dicke, Karel A., Goldman, John M., Good, Robert A., Herzig, Roger H., Hong, Richard, Masaoka, Tohru, Rimm, Alfred A., Ringden, Olle, Speck, Bruno, Weiner, Roy S., Bortin, Mortimer M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biological and medical sciences
Bone Marrow Transplantation - immunology
Child
Child, Preschool
Combined Modality Therapy
Female
Graft Rejection
Graft vs Host Disease - prevention & control
Hematologic and hematopoietic diseases
HLA Antigens - analysis
Humans
Infant
Leukemia - drug therapy
Leukemia - surgery
Lymphocyte Depletion
Male
Medical sciences
Middle Aged
T-Lymphocytes
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Beschreibung
Zusammenfassung:We analyzed the effects of T-cell depletion on the outcome of HLA-identical sibling bone marrow transplants for leukemia by comparing 731 T-cell-depleted transplants with 2,480 non-T-cell-depleted transplants. T-cell depletion decreased acute graft-versus-host disease (GVHD) (relative risk [RR] 0.45; P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V78.8.2120.2120