Transcript mutations of the α regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterised by diverse dysfunctions of immune effector cells, including proliferation and cytotoxicity. In T cells from patients with SLE, activity of type 1 protein kinase A isozymes is greatly reduced because of decreased expression of...

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Veröffentlicht in:	The Lancet (British edition) 2002-09, Vol.360 (9336), p.842-849
Hauptverfasser:	Laxminarayana, Dama, Khan, Islam U, Kammer, Gary M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - genetics Adult Base Sequence - genetics Biological and medical sciences Cohort Studies Cyclic AMP-Dependent Protein Kinase RIalpha Subunit Cyclic AMP-Dependent Protein Kinases - genetics DNA Mutational Analysis DNA, Complementary - genetics Female Gene Expression - physiology Gene Frequency Humans Hypnotics. Sedatives Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Medical sciences Mutation - genetics Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Ribonucleoproteins RNA Editing - genetics RNA, Messenger - genetics RNA-Binding Proteins RNA-Induced Silencing Complex T-Lymphocytes - metabolism Transcription, Genetic - genetics Up-Regulation - genetics
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