A Novel Neuritogenic Compound, NGA0187

A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of spectroscopic analysis and X-Ray diffraction. NGA0187 induced significant neurite outgrowth in PC12 cells. However, survival effect of NGA0187 o...

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Veröffentlicht in:	Journal of antibiotics 2002/07/25, Vol.55(7), pp.629-634
Hauptverfasser:	NOZAWA, YURIKO, SAKAI, NORIYOSHI, MATSUMOTO, KEITA, MIZOUE, KAZUTOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Agaricales - classification Agaricales - metabolism Animals Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Cerebral Cortex - cytology Cerebral Cortex - drug effects Crystallography, X-Ray Drug Evaluation, Preclinical Fermentation Fundamental and applied biological sciences. Psychology General aspects Magnetic Resonance Spectroscopy Microbiology Molecular Structure Nerve Growth Factors - chemistry Nerve Growth Factors - isolation & purification Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Neurites - drug effects Neurons - cytology Neurons - drug effects PC12 Cells Rats Rats, Wistar Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Beschreibung
Zusammenfassung:	A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of spectroscopic analysis and X-Ray diffraction. NGA0187 induced significant neurite outgrowth in PC12 cells. However, survival effect of NGA0187 on the primary culture of cerebral cortical neurons was not observed.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.55.629